摘要
细胞蛇是一种由代谢相关的酶组成的“杆”或“环”状结构。肌苷-5’-单磷酸脱氢酶(inosine-5’-monophosphate dehydrogenase,IMPDH)是催化鸟嘌呤核苷酸的从头生物合成途径中的限速酶,在细胞增殖、细胞分化、维持机体平衡以及新陈代谢中扮演着非常重要的角色。研究发现,IMPDH2蛋白可以组装成一种特殊结构的蛋白质聚合物纤维,命名为IMPDH2细胞蛇,该结构是与嘌呤代谢相关的天然生物学现象,作为微调蛋白适应细胞内和细胞外的环境变化。本综述对IMPDH2及IMPDH2细胞蛇的结构、IMPDH2细胞蛇的组装过程及影响因素进行综述。
Cytoophidium is a"rod"or"ring"structure composed of metabolically related enzymes.Inosine-5’-monophosphate dehydrogenase(IMPDH)is a rate-limiting enzyme that catalyzes the de novo biosynthetic pathway of guanine nucleotides and plays a very important role in cell proliferation,cell differentiation,maintenance of body balance and metabolism.The study found that IMPDH2 protein can be assembled into a special structure of protein polymer fibers,named IMPDH2 cytoophidia,the structure was a natural biological phenomenon related to purine metabolism,as a fine-tuning protein adapted to the intracellular and extracellular environment changes.This article reviews the structure of IMPDH2 and IMPDH2 cytoophidia,the assembly process and the influencing factors of IMPDH2 cytoophidia.
作者
史丽维
张伟伟
Shi Liwei;Zhang Weiwei(Key Laboratory of Heilongjiang Province for Resistance Gene Engineering and Protection of Biodiversity in Cold Areas,College of Life Sciences,Agriculture and Forestry,Qiqihar University,Qiqihar,161006)
出处
《基因组学与应用生物学》
CAS
CSCD
北大核心
2021年第7期2889-2894,共6页
Genomics and Applied Biology
基金
国家青年科学基金项目(31801148)
黑龙江省自然科学基金项目(C2016057,C201241)
黑龙江省教育厅基本业务专项(135209260)
黑龙江省省属高等学校基本科研业务费科研项目(YSTSXK201874)共同资助
