摘要
目的探讨右美托咪定在剖宫产手术麻醉及术后镇痛的临床效果。方法选择2019年5月至2020年5月择期行剖宫产手术的初产妇128例作为研究对象,根据用药情况分为右美托咪定组70例和哌替啶组58例,比较2组不同时间段平均动脉压及心率。右美托咪定组分为对照组和试验组,试验组予芬太尼400μg+右美托咪定300μg+0.9%氯化钠溶液共100 ml泵入,对照组予芬太尼400μg+NS共100 ml泵入,比较试验组和对照组患者在不同时间段手术切口痛VAS评分、宫缩痛的VAS评分,及术后24、48 h镇痛泵按压次数和药物消耗量。结果右美托咪定组在麻醉前、麻醉后、胎儿娩出时及手术后30 min与哌替啶组相比差异有统计学意义(P<0.05)。对照组、试验组在手术结束时切口痛和宫缩痛差异无统计学意义(P>0.05)。剖宫产术后右美托咪定试验组和对照组在切口痛和宫缩痛VAS评分差异无统计学意义(P>0.05),对照组术后12 h、24 h、48 h的手术切口痛、宫缩痛VAS评分高于试验组,差异有统计学意义(P<0.05)。对照组术后24 h、48 h镇痛泵按压次数和药物消耗量显著高于试验组,差异有统计学意义(P<0.05)。结论右美托咪定在剖宫产手术麻醉及术后镇痛中应用效果显著,平均动脉压、心率波动较小,术后切口痛和宫缩痛VAS评分低,镇痛效果良好。
Objective To investigate the analgesic effects of dexmedetomidine in anesthesia and postoperative analgesia during cesarean section.Methods A total of 128 primipara who underwent elective cesarean section in our hospital from May 2019 to May 2020 were enrolled in the study,who were divided into dexmedetomidine group(n=70)and pethidine group(n=58).Moreover dexmedetomidine group was redivided into control group and experimental group.The primipara in experimental group were given sufentanil 100μg+dexmedetomidine 300μg+NS 100ml,however,the primipara control group were given sufentanil 100μg+NS 100ml.The VAS scores of surgical incision pain and contractive pain in different periods,and the number of analgesic pump presses and drug consumption at 24h and 48h after operation were observed and compared between the two groups.Results There were significant differences between dexmedetomidine group and pethidine group before and after anesthesia,during delivery and 30min after operation(P<0.05).There were no significant differences in incision pain scores and contractions pain scores at the end of operation between control group and experimental group(P>0.05).After cesarean section,there were no significant differences in the VAS scores of incision pain and contraction pain between experimental group and control group(P>0.05),however,which at 12h,24h and 48h after surgery in control group were significantly higher than those in experimental group(P<0.05).moreover the number of analgesia pump press and drug consumption in control group at 24h and 48h after surgery were significantly higher than those in experimental group(P<0.05).Conclusion The application effects of dexmedetomidine in cesarean section anesthesia and postoperative analgesia are significant,with smaller fluctuation of mean arterial pressure and heart rate,lower VAS scores for postoperative incision pain and contractions pain,and better analgesic effects.
作者
谭燕
何芳
钟长云
TAN Yan;HE Fang;ZHONG Changyun(Department of Anesthesiology,Mianyang People’s Hospital,Sichuan,Mianyang 621000,China;不详)
出处
《河北医药》
CAS
2022年第4期539-542,共4页
Hebei Medical Journal
关键词
右美托咪定
哌替啶
剖宫产
麻醉
镇痛
dexmedetomidine
pethidine
cesarean section
anesthesia
analgesia
