摘要
周围组织的感染和持续性低度炎症是抑郁症的重要致病因素。抑郁症通常与全身性炎症性疾病/病症相关,如牙周炎等。牙周炎是牙周组织的感染性疾病,牙周炎患者抑郁症的发病率高于非牙周炎患者。抑郁症和牙周炎之间很可能存在着一定的关系,且其潜在机制可能为免疫介导的慢性全身性炎症。本文重点介绍牙周炎与抑郁症的生物学和流行病学证据,并对两者间相关性研究进展进行综述。
Infection and persistent low-grade inflammation in peripheral tissues are important pathogenic factors in depression.Depression is usually related to systemic inflammatory diseases/conditions,such as periodontitis.Periodontitis is an infectious disease of the periodontal tissues.It has also been clinically observed that the incidence of depression in periodontitis patients is higher than that in non-periodontitis patients.There may be a certain relationship between depression and periodontitis,and the underlying mechanism of this relationship may be immune-mediated chronic systemic inflammation.In this review,we focus on the biological and epidemiological evidence of periodontitis and depression,and review the research progress in the correlation between the two.
作者
范凯健
曹丰弟
王丽彬
李红梅
张晔
FAN Kai-jian;CAO Feng-di;WANG Li-bin;LI Hong-mei;ZHANG Ye(Department of Pharmacy,Mental Health Center of Chongming District,Shanghai 202150,China;Department of Psychiatry,Mental Health Center of Chongming District,Shanghai 202150,China;University of Melbourne&Melbourne Dental school,Grattan Street Park ville,Melbourne,VIC 3010,Australia;Department of Stomatology of the First Affiliated Hospital of Jinan University&School of Stomatology,Jinan University,Guangzhou 510632,China)
出处
《实用药物与临床》
CAS
2022年第2期187-192,共6页
Practical Pharmacy and Clinical Remedies
基金
上海市崇明区科委科技项目(CKY2020-15)
广东省医学科研基金青年项目(B2018110)。
关键词
炎症
牙周炎
抑郁症
Inflammation
Periodontitis
Depression
