摘要
目的探讨主动脉瘤发生与牙周炎、血糖和血脂的相关性。方法选取2011年8月至2012年3月首都医科大学附属北京安贞医院收治的主动脉瘤患者94例作为观察组,选取同期在口腔科门诊自愿行口腔检查者78例作为对照组。比较2组牙周炎发生情况及严重程度,比较空腹血糖、三酰甘油、总胆固醇、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,分析主动脉瘤与牙周炎、血糖及血脂水平的相关性。结果 2组一般临床资料比较差异均无统计学意义(均P> 0. 05)。观察组牙周炎发生率明显高于对照组[83. 0%(78/94)比42. 3%(33/78)](P <0. 001),且观察组牙周炎严重程度明显重于对照组(Z=7. 502,P=0. 024)。观察组空腹血糖和LDL-C水平明显高于对照组[(6. 9±1. 2) mmol/L比(6. 1±0. 9) mmol/L、(3. 1±0. 6) mmol/L比(2. 6±0. 6) mmol/L](均P <0. 001)。主动脉瘤合并不同程度牙周炎患者随着牙周炎疾病程度加重,空腹血糖和LDL-C水平明显升高(P <0. 05)。Pearson相关分析结果显示,主动脉瘤发生与牙周炎、牙周炎严重程度、空腹血糖和LDL-C水平均呈正相关(r=0. 715,P=0. 001; r=0. 622,P=0. 002; r=0. 497,P=0. 018; r=0. 488,P=0. 020)。结论主动脉瘤发生与牙周炎、血糖及血脂具有明显相关性,控制牙周炎发生率及血糖和血脂水平对降低主动脉瘤发生率有重要意义。
Objective To investigate the relation between periodontitis, blood glucose, blood lipid and aortic aneurysm. Methods From August 2011 to March 2012, 94 patients with aortic aneurysm(observation group) and 78 patients who had oral health examination(control group) at Beijing Anzhen Hospital, Capital Medical University were enrolled. Incidence and severity of periodontitis, serum levels of fasting blood glucose(FPG), triglyceride, total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein(LDL-C) were analyzed. Results Basic clinical information was similar between groups(P>0.05). Incidence of periodontitis[83.0%(78/94) vs 42.3%(33/78)](P<0.001) and the severity of disease(Z=7.502, P=0.024) in the observation group were higher/worse than those in the control group. FPG and LDL-C levels in the observation group were higher than those in the control group[(6.9±1.2)mmol/L vs (6.1±0.9)mmol/L, (3.1±0.6)mmol/L vs (2.6±0.6)mmol/L](both P<0.001). FPG and LDL-C levels increased with the severity of periodontitis(P<0.05). Pearson analysis showed that aortic aneurysm was positively correlated with periodontitis, periodontitis severity, FPG and LDL-C(r=0.715, P=0.001;r=0.622, P=0.002;r=0.497, P=0.018;r=0.488, P=0.020). Conclusion Aortic aneurysm is significantly related with periodontitis, blood glucose and blood lipid.
作者
李晓丽
丁芳
吕亚林
Li Xiaoli;Ding Fang;Lyu Yalin(Department of Stomatology,Beijing Artzhen Hospital,Capital Medical University,Beijing 100029,China)
出处
《中国医药》
2019年第2期183-186,共4页
China Medicine
基金
国家自然科学基金(81641159)~~
关键词
主动脉瘤
牙周炎
血糖
血脂
Aortic aneurysm
Periodontitis
Blood glucose
Blood lipid
