摘要
目的:探讨益肾壮骨散结合饮食、运动干预对原发性骨质疏松性椎体压缩性骨折(OVCF)术后患者的疗效。方法:将120例OVCF术后患者以随机数字表法分为对照组与观察组各60例,对照组在口服钙剂的基础上配合饮食、运动治疗;观察组在对照组的基础上联合益肾壮骨散口服,两组均治疗1个月。对比分析两组治疗前后的骨代谢相关临床指标[血清骨钙素(OCN)、骨特异性碱性磷酸酶(BALP)、吡啶酚(PYD)]及骨密度变化,并评估其疗效和不良反应情况。结果:观察组治疗总有效率96.67%,对照组85.00%,两组疗效比较,差异有统计学意义(P<0.05);治疗后两组第2~4腰椎、股骨转子及股骨颈处骨密度均较治疗前升高(P<0.05),且观察组高于对照组(P<0.05);治疗后两组血清OCN水平较治疗前升高,BALP、PYD水平较治疗前降低,且观察组各指标改善程度优于对照组(均P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05),对症处理后均缓解。结论:益肾壮骨散结合饮食、运动干预对OVCF术后患者疗效确切,能有效促进骨密度增长,改善其骨代谢状况及骨质疏松程度,且安全性较高。
Objective:To investigate the effect of Yishen Zhuanggu Powder(益肾壮骨散)combined with diet and exercises intervention on bone mineral density in patients with primary osteoporotic vertebral compression fracture(OVCF)after operation.Methods:One hundred and twenty patients with primary OVCF were divided into control group and observation group by random number table method,60 patients in each group.The control group was treated with diet and exercises on the basis of oral administration of calcium.The observation group was treated with Yishen Zhuanggu Powder besides the treatment of the control group.The two groups were treated for one month.The changes of bone metabolism related clinical indicators[serum osteocalcin(OCN),bone alkaline phosphatase(BALP),pyridinidase(PYD)]and bone mineral density(BMD)before and after treatment were compared and analyzed,and the curative effect and adverse reactions were recorded.Results:The effective rate of the observation group was 96.67%,and in the control group was 85.00%.The difference between both groups on the curative effect was statistically significant(P<0.05).The BMD of L2~4,femoral trochanter and femoral neck in the two groups after treatment were significantly higher than that before treatment,and those in the observation group after treatment were higher than those of the control group(P<0.05).The serum level of OCN after treatment increased compared with before treatment,while levels of BALP and PYD decreased after treatment compared with before treatment,and the changes of each index in the observation group were better than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Yishen Zhuanggu Powder combined with diet and exercise intervention has a definite effect on patients with OVCF after operation.It can effectively promote the growth of BMD,improve the bone metabolism and the degree of osteoporosis,and has high safety.
作者
张晓峰
宋立锋
马红卫
陈红娟
檀秋华
柴伟杰
ZHANG Xiaofeng;SONG Lifeng;MA Hongwei;CHEN Hongjuan;TAN Qiuhua;CHAI Weijie(The First Department of Orthopedics,Xinle Traditional Chinese Medicine Hospital,Xinle 050700,China)
出处
《山东中医杂志》
2022年第3期276-280,共5页
Shandong Journal of Traditional Chinese Medicine
基金
河北省中医药管理局项目(编号:2018297)。
关键词
益肾壮骨散
饮食
运动
原发性骨质疏松症
椎体压缩性骨折
骨密度
Yishen Zhuanggu Powder
diet
exercise
primary osteoporosis
vertebral compression fracture
bone mineral density
