摘要
制备葛根素水飞蓟宾共无定形体系,提高水飞蓟宾溶出速率及稳定性。通过喷雾干燥法制备葛根素水飞蓟宾共无定形,利用粉末X射线衍射法、偏振光显微镜、傅里叶红外光谱法、差示扫描量热分析等表征其固态特征,并进一步研究其过饱和粉末溶出、特性溶出速率、引湿性及稳定性。结果发现葛根素水飞蓟宾形成了具有单一玻璃化转变温度的共无定形系统,其玻璃化转变温度高于任一单体;共无定形体系中水飞蓟宾的特性溶出速率和过饱和粉末溶出均高于原料药及无定形;在40℃,75%相对湿度条件下稳定性高达3个月,高于无定形水飞蓟宾单体。因此,共无定形技术能显著改善水飞蓟宾的溶出行为和稳定性。
The present study explored the effect of co-amorphous technology in improving the dissolution rate and stability of silybin based on the puerarin-silybin co-amorphous system prepared by the spray-drying method.Solid-state characterization was carried out by powder X-ray diffraction(PXRD),polarizing microscopy(PLM),Fourier transform infrared spectroscopy(FT-IR),differential scanning calorimetry(DSC),etc.Saturated powder dissolution,intrinsic dissolution rate,moisture absorption,and stability were further investigated.The results showed that puerarin and silybin formed a co-amorphous system at a single glass transition temperature which was higher than that of any crude drug.The intrinsic dissolution rate and supersaturated powder dissolution of silybin in the co-amorphous system were higher than those of the crude drug and amorphous system.The co-amorphous system kept stable for as long as three months under the condition of 40℃,75%relative humidity,which was longer than that of the single amorphous silybin.Therefore,the co-amorphous technology could significantly improve the dissolution and stability of silybin.
作者
刘欢
赵国巍
蒋且英
梁新丽
欧阳料淇
丁海波
陈绪龙
廖正根
LIU Huan;ZHAO Guo-wei;JIANG Qie-ying;LIANG Xin-li;OUYANG Liao-qi;DING Hai-bo;CHEN Xu-long;LIAO Zheng-gen(Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;Laboratory Animal Science and Technology Center,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2022年第1期103-110,共8页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81660757)
江西省一流学科项目(JXSYLXK-ZHYAO059)。
