摘要
化学药品的晶型研究十分广泛,但中药中活性化学成分的多晶型现象尚未引起足够重视。该文以无水的脱水穿心莲内酯和含水的升麻素苷为代表,采用显微、熔点、差热分析和红外光谱技术探讨了不同晶型中药化学对照品的差异。结果表明晶型不同会引起熔点、热行为和红外光谱的改变。提示在应用中药化学对照品时如得到不同的指标测定结果,须考虑多晶型的存在。不同晶型的中药活性成分的化学性质差异尚待深入研究。
Crystal structures of chemical drugs has been being investigated widely. But few attention has been paid to polymorphs- phenomena of active ingredients from Traditional Chinese Medicine（TCM）. Taking anhydrous dehydroandrographolide and hydrousprim- O-glucosylcimifugin as example, differences between TCM reference substances （RSs） with different crystal structures were discussed by using microscopy, melting point determination, differential thermal analysis （DTA） and infrared （IR） methods. The results showed that different crystal structures could lead to change of melting points, thermal behaviors and IR spectrum. It＇s indicated that poly- morphs may be considered if different physicochemical properties were obtained when applying TCM RS. Differences of chemical prop- erties of active ingredients from TCM with different crystal structures need further investigation.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2015年第16期3245-3248,共4页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81303194)
国家"重大新药创制"科技重大专项(2014ZX09304307-02)
关键词
中药化学对照品
晶型
差热分析
红外
TCM reference substance （ TCM RS）
crystal structure
differential thermal analysis （DTA）
infrared （IR）
