摘要
目的评价柴胡疏肝散治疗肿瘤相关性抑郁(cancer related depression,CRD)肝郁脾虚证临床疗效。方法将符合入选标准的2018年9月-2019年10月本院肿瘤科63例CRD患者,采用随机化方法产生随机编码按2∶1比例分为观察组42例、对照组21例。观察组给予柴胡疏肝散颗粒剂,对照组给予柴胡疏肝散模拟剂(2%原药+糊精)。2组均连续用药42 d。分别于治疗前后进行中医证候评分,采用汉密尔顿抑郁量表(HAMD24)评估抑郁程度,评价临床疗效。结果观察组抑郁疗效总有效率为71.4%(30/42)、对照组为14.3%(3/21),2组比较差异有统计学意义(Z=-4.22,P<0.01);观察组治疗后HAMD-24评分[(18.67±3.55)分比(24.71±3.74)分,t=-2.12]低于对照组(P<0.05)。观察组中医证候疗效总有效率为71.4%(30/42)、对照组为14.3%(3/21),2组比较差异有统计学意义(Z=-4.00,P<0.01);观察组中医证候评分[(55.33±17.59)分比(62.04±10.72)分,t=-2.00]低于对照组(P<0.05)。结论柴胡疏肝散可有效改善CRD肝郁脾虚证患者焦虑抑郁状态,提高疗效。
Objective To evaluate the clinical effect of Chaihu Shugan Powder in the treatment of liver qi and spleen deficiency syndrome on cancer related depression(CRD).Methods A total of 63 patients with cancer related depression from our hospital during September 2018 to October 2019 were divided into observation group(42 cases)and control group(21 cases)according to the ratio of 2:1.The observation group was applied with Chaihu Shugan Powder,while the control group was given placebo agent of Chaihu-Shugan with 2%Chaihu-Shugan Powder and 98%dextrin.Both groups were treated continuously for 42 days.We used HAMD24 and Traditional Chinese Medicine(TCM)Symptoms Scale to evaluate both before and after treatment.Results The total efficiency about depression in the observation group was 71.4%(30/42)while the control group was 14.3%(3/21).The difference was statistically significant(Z=-4.22,P<0.01).After treatment,The HAMD scales of the observation group was 18.67±3.55 while the control group was 24.71±3.74(P<0.05).The total effective rate of TCM syndrome in the observation group was 71.4%(30/42)and that in the control group was 14.3%(3/21).There was significant difference between the two groups(Z=-4.00,P<0.01).TCM Syndrome Score of observation group was 55.33±17.59 while the control group was 62.04±10.72(t=-2.00,P<0.05).Conclusion Chaihu Shugan Powder can effectively improve the anxiety and depression of CRD patients with syndrome of stagnation of liver qi and spleen deficiency.
作者
邓海燕
武胜萍
吴晓芳
刘丹
Deng Haiyan;Wu Shengping;Wu Xiaofang;Liu Dan(Department of Oncology,Beijing Hospital of Integrated Traditional Chinese and Western Medicine,Beijing 100013,China)
出处
《国际中医中药杂志》
2022年第2期150-153,共4页
International Journal of Traditional Chinese Medicine
基金
北京市中医药科技发展基金资助项目(JJ2018-29)
全国中医药创新骨干人才培训项目(国教函〔2019〕128号)。
关键词
柴胡疏肝散
郁证
肿瘤相关性抑郁
Chai Hu Shu Gan San
Melancholia
Cancer related depression
