摘要
本研究建立了羊髌腱缺损重建动物实验模型,通过手术对动物实验羊后肢肌腱进行剥离,分别使用均匀多孔结构与仿生多孔结构钛合金植入体重建其膑腱附丽点,并在术后1、3、6个月后设置观察点,采用活体运动观察、大体观察、X射线分析、组织学观察、Micro-CT检测、骨质三维重建与生物力学检测等手段,重点研究了不同结构多孔钛合金植入体对肌腱的愈合效果。结果表明均匀多孔结构与仿生多孔结构植入体均能使肌腱实现良好的愈合,新生肌腱组织可以长入钛合金植入物的多孔结构中,并且其结合强度随术后恢复时间的延长而逐步增加。此外,本研究还探究了植骨与否对重建后各观察点的肌腱结合强度,发现其影响较弱,但仿生多孔结构抑制骨吸收的效果非常显著。
This study established a scientific animal experimental model.Posterior-limb tendons of small fat-tail sheeps were stripped through surgery.Uniform and bionic porous structural Ti-alloy implants were used respectively to recon⁃struct the patellar tendon attachment points.The intravital motion observation,general observation,X-ray detection,his⁃tology observation,Micro-CT,3D bone reconstruction,biomechanics and other methods were conducted at 1,3,6 months after the operation,focusing on the effects of healing between tendon and porous Ti-alloy implant with different pore structures.The results show that both of the homogeneous and bionic porous structural implants can achieve good tendon healing.The newborn tendon tissue can grow into the porous structure of the Ti-alloy implants,and its binding strength gradually increases with the postoperative recovery time.In addition,this study has also found that the bone graft has a weak effect on binding strength after tendon reconstruction,however,the inhibiting effect of bionic porous structure on bone resorption is more remarkable than that of the homogeneous porous structure.
作者
刘曙光
许奎雪
夏超群
姜红江
李强
张朝锋
王振国
史春宝
LIU Shuguang;XU Kuixue;XIA Chaoqun;JIANG Hongjiang;LI Qiang;ZHANG Chaofeng;WANG Zhenguo;SHI Chunbao(Beijing Chunlizhengda Medical Instrucments Co.,Ltd.,Beijing 101112,China;School of Materials Science and Engineer-ing,Hebei University of Technology,Tianjin 300130,China;Articular Surgery,Shandong Wendeng Orthopedic Hospital,Wei-hai,Shangdong 264400,China;School of Materials Science and Engineering,University of Science and Technology Bei-jing,Beijing 100083,China)
出处
《河北工业大学学报》
CAS
2022年第1期42-53,共12页
Journal of Hebei University of Technology
基金
北京市博士后科研活动经费资助(2021-ZZ-075)
国家重点研发计划(2020YFC1107502)。
