期刊文献+

活血化瘀中药注射剂治疗下肢动脉硬化闭塞症疗效和安全性的系统评价 被引量:4

A Systematic Evaluation of Efficacy and Safety of Traditional Chinese Medicine Injection of Promoting Blood Circulation and Removing Stasis for Treatment of Lower Extremity Arteriosclerosis Obliterans
下载PDF
导出
摘要 目的系统评价活血化瘀中药注射剂治疗下肢动脉硬化闭塞症(ASO)的疗效及安全性。方法计算机检索中国知网、万方、维普数据库中所有活血化瘀中药注射剂治疗ASO的随机对照研究,按照纳入和排除标准筛选文献、提取资料,并依据Cochrane质量评价标准评价纳入研究的方法学质量,采用RevMan 5.4软件根据异质性评价结果选择固定效应模型或随机效应模型进行Meta分析。结果纳入18项随机对照试验,共1555例患者。对16项报道总有效率的研究进行Meta分析显示,观察组的总有效率高于对照组(RR=1.21,95%CI 1.16~1.26,P<0.00001)。根据纳入研究对象的合并症、应用疗程及用药品种的不同开展亚组分析,结果显示不同品种中血栓通注射剂可显著提高治疗总有效率(RR=1.23,95%CI 1.16~1.30,P<0.00001)。10项研究报道踝肱指数改善情况,观察组的踝肱指数高于对照组(MD=0.09,95%CI 0.06~0.13,P<0.00001),两组其他结局指标(最大行走距离、足背动脉血流量、纤维蛋白原、C反应蛋白)比较差异有统计学意义(P<0.01)。5例研究报道了应用药物不良反应发生的情况,两组的药物不良反应发生情况比较差异无统计学意义(P>0.05)。结论加用活血化瘀中药注射剂治疗ASO疗效优于常规治疗,但纳入文献质量相对较差,结论可能存在偏倚,需要大样本、高质量研究进一步证实。 Objective To systematically evaluate the efficacy and safety of traditional Chinese medicine(TCM)injection of promoting blood circulation and removing blood stasis for treatment of lower extremity arteriosclerosis obliterans(ASO).Methods All the randomized controlled studies of ASO treated by TCM injections for promoting blood circulation and removing stasis from CNKI,Wanfang and VIP databases were searched by computer,the literatures were screened and data were extracted according to inclusion and exclusion criteria,and the methodological quality of the included studies was evaluated according to Cochrane quality evaluation criteria.RevMan 5.4 software was used to select fixed effect model or random effect model according to the heterogeneity evaluation results for meta-analysis.Results A total of 18 randomized controlled trials involving 1555 patients were included.The result of meta-analysis of 16 randomized controlled trials with total effective rate reported showed that the total effective rates of the observation groups were significantly higher than those of the control groups(RR=1.21,95%CI 1.16-1.26,P<0.00001).The subgroup analysis was carried out according to the complications,application course and drug varieties included in the study.The results showed that Xueshuantong injection could significantly improve the total effective rate of treatment(RR=1.23,95%CI 1.16-1.30,P<0.00001).There were 10 randomized controlled trials with the change of ankle brachial index reported,and the observation group showed a significantly higher result than that of the control group(MD=0.09,95%CI 0.06-0.13,P<0.00001).There were significant differences in other outcome indexes(maximum walking distance,dorsalis pedis artery blood flow,fibrinogen,C-reactive protein)between the two groups(P<0.01).There were 5 randomized controlled trials with adverse drug reactions reported,and there was no significant difference between two groups(P>0.05).Conclusion TCM injection of promoting blood circulation and removing blood stasis for tre
作者 戴烨 周晨霞 陶赟 江艳 殷秋忆 陈川 梁旭东 DAI Ye;ZHOU Chenxia;TAO Yun;JIANG Yan;YIN Qiuyi;CHEN Chuan;LIANG Xudong(Department of Pharmacy,Changshu Hospital Affiliated to Xuzhou Medical University/Changshu No.2 People′s Hospital,Changshu 215500,China)
出处 《医学综述》 CAS 2022年第4期809-816,共8页 Medical Recapitulate
基金 苏州市产业技术创新专项(SYSD2017162)。
关键词 下肢动脉硬化闭塞症 活血化瘀 中药注射剂 系统评价 Lower extremity arteriosclerosis obliterans Promoting blood circulation and removing blood stasis Traditional Chinese medicine injection Systematic evaluation
  • 相关文献

参考文献34

二级参考文献367

共引文献591

同被引文献84

引证文献4

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部