摘要
目的分析恩替卡韦治疗乙型肝炎的疗效。方法选取2019年1月至2020年1月黑龙江省佳木斯市传染病院108例乙型肝炎患者,采用随机数字表法分为观察组和对照组,观察组(n=54)患者服用恩替卡韦,对照组(n=54)采用干扰素α-2a注射液治疗,比较两组患者临床疗效、ATL复常率、HBV-DNA转阴率、凝血酶原活动度、HBV-DNA应答率、谷丙转氨酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)水平。结果观察组与对照组临床治疗总有效率(96.30%vs.75.93%)比较,差异有统计学意义(P<0.05);观察组ATL复常率(96.30%)、HBV-DNA转阴率(92.59%)均明显高于对照组的77.78%、75.93%,差异有统计学意义(P<0.05);观察组治疗后凝血酶原活动度均明显高于对照组,差异有统计学意义(P<0.001);观察组治疗后HBV-DNA应答率为94.44%,明显高于对照组的79.63%,差异有统计学意义(P<0.05);观察组治疗后谷丙转氨酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)水平明显低于对照组,差异有统计学意义(P<0.001)。结论给予乙型肝炎患者恩替卡韦抗病毒治疗,临床效果明显,可显著提高ATL复常率和HBV-DNA转阴率,并且改善肝功能,对稳定患者病情,避免病情进展具有重要帮助。
Objective To analyze the therapeutic efficacy of adopting entecavir in the treatment of hepatitis B.Methods A total of 108 patients with hepatitis B admitted from January 2019 to January 2020 were selected and divided into the observation group(n=54)and the control group(n=54)according to the random number table method in Jiamusi Infectious Disease Hospital in Heilongjiang Province.The observation group was treated with entecavir,while the control group was treated with interferonα-2a injection.The clinical efficacy,ATL normalization rate,HBV-DNA negative conversion rate,prothrombin activity,the response rate of HBV-DNA,the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBIL)of patients in the two groups were compared.Results The overall response rate of clinical treatment between the observation group and the control group was(96.30%vs.75.93%),with statistically significant difference(P<0.05).The ATL normalization rate(96.30%)and HBV-DNA negative conversion rate(92.59%)in the observation group were all significantly higher than those of 77.78%and 75.93%in the control group,with statistically significant differences(P<0.05).After treatment,the prothrombin activity in the observation group was significantly higher than that in the control group,with statistically significant difference(P<0.001).After treatment,the response rate of HBV-DNA in the observation group was 94.44%,which was significantly higher than that of 79.63%in the control group,with statistically significant difference between the two groups(P<0.05).After treatment,the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBIL)in the observation group were lower than those in the control group,with statistically significant differences(P<0.001).Conclusion Antiviral treatment with entecavir in patients with hepatitis B has obvious clinical efficacy,which can significantly improve ATL normalization rate and HBV-DNA negative conversion rate,and improve hepatic function,w
作者
刘同博
LIU Tongbo(Department of Pharmacy,Jiamusi Infectious Disease Hospital in Heilongjiang Province,Jiamusi154007,China)
出处
《中国现代医生》
2022年第2期116-119,共4页
China Modern Doctor
