摘要
环状RNA(circRNA)是一类具有环状结构且广泛存在的非编码RNA,具有多样性、特异性、保守性和稳定性等特征。作为新兴的非编码调控分子,circRNA主要通过竞争性内源RNA的机制来调控乳腺癌(BC)细胞增殖和转移,并且参与了多种化学药物治疗耐药、影响疗效。阐明circRNA在BC中的功能与机制,将有助于为BC的诊断和治疗提供新颖有效的策略。
Circular RNA(circRNA)is a kind of non-coding RNA with circular structure and is found in a variety of cell types.CircRNA is characterized by diversity,specificity,conservatism and stability.As an emerging non-coding regulatory molecules,circRNA can regulate the proliferation and metastasis of breast cancer(BC)mainly through the mechanism of competitive endogenous RNA,and is involved in a variety of chemotherapy resistance and affect the efficacy.Elucidating the functions and mechanisms of circRNA in BC may provide novel and effective strategies for the diagnosis and treatment of BC.
作者
何啸
胡为杰
吕文昌
任玉萍
吴敏
吴毅平
张奇
HE Xiao;HU Wei-jie;LYU Wen-chang;REN Yu-ping;WU Min;WU Yi-ping;ZHANG Qi(Department of Plastic Surgery, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China)
出处
《基础医学与临床》
2022年第3期507-511,共5页
Basic and Clinical Medicine
基金
中国光华科技基金会(2019JZXM001)
2020年武汉市科技局应用基础前沿专项(2020020601012241)。
