摘要
肺癌是全球最常见、发病率最高的癌症之一,严重影响着人们的身心健康,其中约85%为非小细胞肺癌。近年来,随着低剂量螺旋CT、达芬奇机器人手术和靶向治疗的快速发展,肺癌的治疗效果得到较大改善,但是由于缺乏早期诊断的生物标志物、治疗的靶点和判断预后的标志,大部分患者就诊时已经出现转移,因此肺癌依然是癌症相关死亡的首要原因。环状RNA是一种特殊的内源性非编码RNA,由3'剪接供体位点与5'剪接受体位点反向剪接形成共价闭合环路,具有高度保守性和稳定性,在非小细胞肺癌组织中的表达水平明显异常,与非小细胞肺癌的发生、发展和转移具有密切关系,有望成为一种理想的生物标志物,用于非小细胞肺癌的早期诊断,并提供新的治疗靶点和预后监测点。
Lung cancer is one of the most common cancers in the world,which seriously affects people's physical and mental health.About 85%of them are non-small cell lung cancers.In recent years,with the rapid development of low-dose computed tomography,Da Vinci robotic surgery and targeted therapy,the therapeutic effect of lung cancer has been greatly improved.However,due to the lack of early diagnosis of biomarkers,therapeutic targets and signs of prognosis,most patients have metastases when they are at the time of treatment.Lung cancer remains the leading cause of cancer-related death.CircRNA is a special endogenous non coding RNA,which is formed by the reverse splicing of the 3'splice donor site and the 5'splice acceptor site to form a covalent closed loop.It is highly conservative and stable.The expression level of circRNA in non-small cell lung cancer is obviously abnormal,which is closely related to the occurrence,development and metastasis of non-small cell lung cancer.It is expected to become an ideal biomarker,which is used for early diagnosis of non-small cell lung cancer,and provides new therapeutic targets and prognostic markers.
作者
杨文龙
张国中
任卫东
史宏灿
Yang Wenlong;Zhang Guozhong;Ren Weidong;Shi Hongcan(Department of Cardiothoracic Surgery,Clinical College of Yangzhou University,Yangzhou 225001,China)
出处
《国际外科学杂志》
2019年第3期199-203,共5页
International Journal of Surgery
基金
江苏省科技项目(BL2013023).
关键词
非小细胞肺癌
诊断
分子靶向治疗
预后
非编码RNA
Non-small-cell lung cancer
Diagnosis
Molecular targeted therapy
Prognosis
Noncoding
