摘要
目的分析目前版本的华西肠癌数据库(Database from Colorectal Cancer,DACCA)中,华西医院作为区域性中心所服务的结直肠患者人群的体质量指数(BMI)对肿瘤特征的影响。方法本次数据分析选取的DACCA版本为2021年10月16日更新版,其中分析的数据项目包括:BMI、癌前病变、癌家族史、肿瘤部位、肿瘤形态、肿瘤方位、肿瘤分化程度、肿瘤病理学性质、梗阻、肠套叠、穿孔、疼痛、水肿及出血。以中国成人体质指数分类方法将患者分为为偏瘦、正常、超重及肥胖。结果按照条件筛选DACCA数据库,获得5 761条可分析数据行。χ^(2)检验结果显示,不同BMI分组结直肠癌患者的肿瘤方位(χ^(2)=31.477,P<0.001)不同;秩和检验结果显示,不同BMI分组结肠癌患者的梗阻程度(H=42.490,P<0.001)、肠套叠程度(H=8.179,P=0.042)、水肿程度(H=14.795,P=0.002)和出血程度(H=9.884,P=0.020)比较差异均有统计学意义。结论结直肠癌患者的BMI分类与肿瘤方位和部分肿瘤并发症的发生有关系,BMI偏低者肿瘤更容易累及肠腔1周,更容易出现严重的出血、梗阻、肠套叠状态以及肠壁的重度水肿。
Objective To analyze the impact of body mass index(BMI) on tumor characteristics of colorectal patients served by West China Hospital as a regional center in the current version of Database from Colorectal Cancer(DACCA). Methods The data of DACCA was updated on October 16, 2021. All data items included BMI, precancerous lesions, cancer family, tumor site, tumor morphology, location, differentiation, pathological properties of tumor,obstruction, overlap, perforation, pain, edema, and bleeding. The patients were divided into lean(BMI<18.5 kg/m2),normal(BMI 18.5–23.9 kg/m2), overweight(BMI 24.0–27.9 kg/m2) and obesity(BMI≥28.0 kg/m2) by Chinese classification methods. Results After scanning, 5 761 data rows were analyzed. Chi-square test showed that there was significant difference in the type composition ratio of tumor location in colorectal cancer patients under different BMI groups(χ^(2)=31.477, P<0.001). Rank sum test showed that there was significant difference in the degree of obstruction(H=42.490, P<0.001), intussusception(H=8.179, P=0.042), edema(H=14.795, P=0.002), and bleeding(H=9.884, P=0.020)among different BMI groups. Conclusions The BMI classification of colorectal cancer patients is related to the location of tumor and the occurrence of some tumor complications. Patients with tumor involving intestinal lumens for one week are more likely to have low BMI. The patients with low BMI are more likely to have severe bleeding, obstruction, intestinal intussusception, and severe intestinal wall edema.
作者
詹雯意
刘桂娜
刘莹
赵天浪
汪晓东
李立
ZHAN Wenyi;LIU Guina;LIU Ying;ZHAO Tianlang;WANG Xiaodong;LI Li(Department of Gastrointestinal Surgery,West China Hospital,Sichuan University,Chengdu 610041,P.R.China;West China School of Medicine in Sichuan University,Chengdu 610041,P.R.China)
出处
《中国普外基础与临床杂志》
CAS
2022年第2期232-238,共7页
Chinese Journal of Bases and Clinics In General Surgery
基金
四川大学大学生创新创业项目(项目编号:C2022119081、C2022119392)。
关键词
结直肠癌
肿瘤特征
数据库
大数据
标签
结构化
colorectal cancer
tumor feature
database
big data
the label
structured
