摘要
由于能被多种类型的病原体或危险信号所激活,NLRP3(NOD-like receptor family pyrin domain-containing protein 3)炎症小体在多种疾病过程中都发挥了关键作用.作为炎症反应的核心,NLRP3炎症小体可能为各种炎症性疾病的治疗提供新的靶点.泛素化作为一种多功能翻译后修饰,在NLRP3介导的炎症免疫反应中起着关键的调节作用.通过对NLRP3炎症小体的组成、结构及功能,泛素化过程,泛素化与去泛素化对NLRP3炎症小体的正、负性调控的详细阐述,对NLRP3泛素化靶向治疗的前景与现状深入分析,为炎症性疾病的治疗提供新思路.
NOD-like receptor family pyrin domain-containing protein 3(NLRP3)inflammasomes plays a key role in a variety of disease processes because of its activation by many types of pathogens or danger signals.As the core of inflammatory response,NLRP3 inflammasome may provide a new target for the treatment of various inflammatory diseases.As a multifunctional post-translational modification,ubiquitination plays a key regulatory role in the inflammatory immune response mediated by NLRP3.The study elaborated on the composition,structure and function of NLRP3 inflammasome,the ubiquitination process,and the positive and negative regulation of NLRP3 inflammasome by ubiquitination and deubiquitination,and introduced the targeted therapy effects of NLRP3 ubiquitination,which provided new ideas for the treatment of inflammatory diseases.
作者
许二平
汪保英
栗俞程
白明
Xu Erping;Wang Baoying;Li Yucheng;Bai Ming(Henan Key Laboratory for Modern Research on Zhongjing's Herbal Formulae,Academy of Chinese Medicine Sciences,Henan University of Chinese Medicine,Zhengzhou 450046,China)
出处
《河南师范大学学报（自然科学版）》
CAS
北大核心
2022年第1期123-129,共7页
Journal of Henan Normal University(Natural Science Edition)
基金
国家自然科学基金(81973739)
河南省中医药科学研究重大专项(2018ZYZD09)
河南省优秀青年科学基金(202300410249)
河南省高等学校重点科研项目(20B360013).
