摘要
炎症小体是由多种蛋白组成的复合体，可以激活半胱氨酸天冬氨酸蛋白酶1（caspase-1），活化的caspase-1进一步诱导促炎细胞因子IL-1β和IL—18的成熟和释放，促进细胞炎性坏死（pyroptosis）^[1]。
Inflammasomes are large muhi-protein complexes that serve as a platform for caspase-1 activation,and this process induces subsequent maturation and secretion of the proinflammatory cytokines IL-1β and IL-18,as well as pyroptosis.As an important component of the innate immune system,early activation of inflammasomes in a variety of immune cell subsets can mediate inflammatory response and immunological conditions after burn injury.Here,we review the current knowledge of inflammasomes and its role in immunological and inflammatory response at the early stage of burn injury.
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2014年第3期261-264,共4页
Chinese Journal of Burns
基金
国家自然科学基金（81120108015）
关键词
烧伤
免疫
炎症小体
炎症反应
Burns
Immunity
Inflammasome
Inflammatory response
