摘要
目的:了解热带地区海南省耐多药肺结核患者流行病学特征,为海南省耐多药肺结核防控提供基础数据和理论依据。方法:采用回顾性描述流行病学研究方法。收集2014年1月1日~2019年12月31日海南省结核病定点医院(海南医学院第二附属医院)耐多药肺结核患者临床信息进行统计分析。结果:海南省2014~2019年肺结核患者耐多药率为24.9%(369/1484),初治肺结核患者耐多药率为8.0%(63/791),复治肺结核患者耐多药率为44.2%(306/693)。初治肺结核患者耐多药率以每年0.05%的速度下降,然而复治肺结核患者耐多药率以每年0.03%的速度增加。耐多药肺结核病患者主要分布在海口市(83例)、儋州市(44例)、文昌市(42例)、万宁市(37例)和东方市(32例),这5个地区共有238例耐多药肺结核患者,占所有病例的64.5%。369例耐多药肺结核病患者中,男性占81.0%。初治患者占比为17.1%(63/369),然而复治患者占比为82.9%(306/369),显著高于初治患者。不同年份肺结核病患者耐多药率存在差异。结论:海南省肺结核病患者耐药率高于全国平均水平,需要引起重视。不同治疗史耐多药肺结核患者流行病学特征存在差异性。
Objective:To investigate the epidemic characteristics of multidrug resistant tuberculosis in Hainan,a tropical region of China and to provide basic information and theories for the prevention and control of multidrug resistant tuberculosis.Methods:A retrospective descriptive epidemiological study was conducted.Data of patients with multidrug resistant tuberculosis in Hainan Island from January 1,2014 to December 31,2019 were collected for statistical analysis.Results:From 2014 to 2019,the multidrug resistant rate of tuberculosis in Hainan Island was 24.9%(369/1484),multidrug resistant rate of tuberculosis was 8.0%(63/791)in the newly-treated,and 44.2%(306/693)in the retreated.The multidrug resistant rate of newly-treated tuber-culosis decreased by 0.05%per year,while that of retreated tuberculosis increased by 0.03%per year.Multidrug resistant tubercu-losis was mainly distributed in Haikou(83 cases),Danzhou(44 cases),Wenchang(42 cases),Wanning(37 cases)and Dong-fang(32 cases),a total of 238 cases accounting for 64.5%of all multidrug resistant tuberculosis cases.Among 369 multidrug resis-tant tuberculosis cases,81.0%were male.The proportion of newly-treated cases was 17.1%(63/369),while the proportion of retreated cases was 82.9%(306/369),which was significantly higher than that of newly-treated cases.The multidrug resistant rate of tuberculosis varied with years.Conclusion:The drug resistance rate of tuberculosis in Hainan Island is higher than the coun-try's average level,which needs attention.The epidemiological characteristics of multidrug resistant tuberculosis with different treatment history are different.
作者
赵秀娟
刘琳
吴兴勇
符慧敏
刘彪
裴华
夏乾峰
ZHAO Xiu-juan;LIU Lin;WU Xing-yong;FU Hui-min;LIU Biao;PEI Hua;XIA Qian-feng(Laboratory of Tropical Biomedicine and Biotechnology,Hainan Medical University,Haikou 571199,China;Key Laboratory of Tropical Translational Medicine of Ministry of Education and School of Tropical Medicine and Laboratory Medicine,Hainan Medical University,Haikou 571199,China;Public Health School,Hainan Medical University,Haikou 571199,China;Laboratory Department,the Second Affiliated Hospital,Hainan Medical University,Haikou 571199,China)
出处
《海南医学院学报》
CAS
2022年第3期166-170,180,共6页
Journal of Hainan Medical University
基金
国家科技重大专项(2018ZX10101003-001-009)
国家自然科学基金项目(81960002、81860002)
海南医科大学热带医学与检验医学院/研究培养基金(1021/XPY180017)资助项目
关键词
结核分枝杆菌
耐多药结核病
时间分布
地区分布
人群分布
Mycobacterium tuberculosis
Multi-drug resistant tuberculosis
Time distribution
Regional distribution
Pop-ulation distribution
