摘要
目的了解2012—2022年广东省深圳市罗湖区肺结核患者利福平和异烟肼耐药情况及变化趋势,为耐药结核病的防控提供依据。方法通过中国疾病预防控制信息系统结核病监测报告管理系统收集2012—2022年罗湖区病原学检测阳性的肺结核患者的基本信息、治疗分类和耐药情况等资料,描述性分析利福平和异烟肼耐药率及变化趋势。结果纳入肺结核患者2126例,年龄M(QR)为34(25)岁。男性1334例,占62.75%;女性792例,占37.25%。2012—2022年罗湖区耐药肺结核患者302例,耐药率为14.21%,其中单耐利福平患者60例,耐药率为2.82%;单耐异烟肼患者113例,耐药率为5.32%;耐多药患者129例,耐多药率为6.07%。2012—2022年单利福平耐药率呈下降趋势(P<0.05),耐多药率呈上升趋势(P<0.05),单异烟肼耐药率无明显变化趋势(P>0.05)。非深圳市户籍患者耐多药率高于深圳市户籍患者;复治患者单利福平耐药率、耐多药率高于初治患者(均P<0.05)。结论2012—2022年罗湖区肺结核患者单利福平耐药率呈下降趋势,耐多药率呈上升趋势。应重点关注非深圳市户籍和复治的肺结核患者。
Objective To investigate the resistance to rifampicin and isoniazid and the changing trends among patients with pulmonary tuberculosis in Luohu District,Shenzhen City,Guangdong Province from 2012 to 2022,so as to provide insights into improving drug-resistant pulmonary tuberculosis control and prevention strategies.Methods Basic information,treatment classification and drug resistance data of patients with pulmonary tuberculosis and positive pathogenic detection in Luohu District from 2012 to 2022 were collected through the Tuberculosis Surveillance System of Chinese Disease Prevention and Control Information System,and resistance rates of rifampicin and isoniazid and the changing trends were analyzed.Results A total of 2126 patients with pulmonary tuberculosis were collected and had a median age of 34(interquartile range,25)years,including 1334 males(62.75%)and 792 females(37.25%).There were 302 patients with drug-resistance in Luohu District from 2012 to 2022,with a resistance rate of 14.21%.Among them,60 patients were monoresistant to rifampicin(2.82%),113 patients were monoresistant to isoniazid(5.32%),and 129 patients were multidrug resistant(6.07%).The rate of rifampicin monoresistance showed a downward trend from 2012 to 2022,while the rate of multidrug resistance showed an upward trend(both P<0.05).There was no significant tendency in the rate of isoniazid monoresistance(P>0.05).The rate of multidrug resistance among patients without Shenzhen residence was higher than that among patients with Shenzhen residence;the rates of rifampicin resistance and multidrug resistance among retreated patients were higher than those among treatment-naïve patients(all P<0.05).Conclusions The rate of rifampicin monoresistance appeared a downward trend and the rate of multidrug resistance appeared an upward trend among patients with pulmonary tuberculosis in Luohu District from 2012 to 2022.Attention should be given to non-Shenzhen residence and retreated patients.
作者
唐小芬
秦道新
金凤霞
田园
邹永霞
沈玉蓉
刘瑶
谢秀钗
TANG Xiaofen;QIN Daoxin;JIN Fengxia;TIAN Yuan;ZOU Yongxia;SHEN Yurong;LIU Yao;XIE Xiuchai(Luohu District Chronic Disease Hospital,Shenzhen,Guangdong 518020,China)
出处
《预防医学》
2024年第6期536-539,共4页
CHINA PREVENTIVE MEDICINE JOURNAL
关键词
肺结核
利福平
异烟肼
耐药
耐多药
pulmonary tuberculosis
rifampicin
isoniazid
drug resistance
multidrug resistance
