摘要
目的探讨益生菌对超重肥胖孕妇妊娠期糖尿病(GDM)的预防效果。方法采用Meta分析的方法,通过国内外数据平台检索并筛选相关文献,对其进行方法学质量评价并使用RevMan5.4统计软件对结果进行分析。结果最终纳入5篇文献。Meta分析结果显示,益生菌可有效控制妊娠期空腹血糖(P<0.05),降低GDM的发病率(P<0.05),但对妊娠期体质量增加无影响(P=0.80)。相比之下,服用较长时间(≥8周)益生菌对GDM的预防效果更为显著(P<0.05)。结论益生菌可有效预防超重肥胖孕妇患GDM,开展更多高质量研究,统一干预措施及干预时间进一步验证,对于预防妊娠期并发症具有非常重要的意义。
Objective To investigate the preventive effect of probiotics on gestational diabetes mellitus(GDM) in overweight and obese women.Methods The meta-analysis method was used to search the domestic and foreign databases for random controlled trials that met the inclusion and exclusion criteria,and the quality of the included literature was evaluated.The RevMan5.4 software was used for statistical analysis of the extracted data.Results Five articles were included.The results of Meta-analysis showed that probiotics could effectively control fasting blood glucose during pregnancy(P<0.05) and reduce the incidence of gestational diabetes mellitus(P<0.05),but had no effect on gestational weight gain(P=0.80).In contrast,longer duration(≥8 weeks) of probiotics had a more significant protective effect on gestational diabetes(P<0.05).Conclusion Probiotics can effectively prevent gestational diabetes in overweight and obese women.It is of great significance to carry out more high-quality studies,unify intervention measures and intervention time for further verification,for the prevention of pregnancy complications.
作者
张一丁
孙华
尹婷
赵春善
ZHANG Yi-Ding;SUN Hua;YIN Ting(Nursing College,Beihua University,Jilin,Jilin 132013,China)
出处
《中国妇幼保健》
CAS
2022年第2期382-385,F0004,共5页
Maternal and Child Health Care of China
基金
吉林省教育厅“十三五”科学技术项目(JJKH20200061KJ)。
关键词
益生菌
妊娠期糖尿病
META分析
随机对照试验
Probiotics
Gestational diabetes mellitus
Meta analysis
Randomized controlled trial
