摘要
目的探析注射用重组人TNK组织型纤溶酶原激活剂(rhTNK-tPA)溶栓治疗急性ST段抬高型心肌梗死的效果。方法32例急性ST段抬高型心肌梗死患者作为研究对象,以治疗方式的不同分为参照组及研究组,每组16例。参照组应用尿激酶治疗,研究组应用rhTNK-tPA治疗。对比两组溶栓治疗后90 min行冠状动脉造影患者的冠状动脉造影结果,溶栓治疗后终点事件发生率,溶栓治疗后90 min未行冠状动脉造影患者的血管再通率。结果研究组溶栓治疗后90 min行冠状动脉造影患者的梗死相关血管(IRA)心肌梗死溶栓治疗(TIMI)3级、IRA TIMI 2~3级血流再通率分别为83.33%、91.67%,均高于参照组的38.46%、46.15%,差异具有统计学意义(P<0.05)。两组溶栓治疗后死亡(30 d内)、靶血管重建术、心肌缺血复发、心源性休克、再梗死、其他并发症发生率对比,差异无统计学意义(P>0.05)。两组溶栓治疗后90 min未行冠状动脉造影患者的血管再通率对比,差异无统计学意义(P>0.05)。结论急性ST段抬高型心肌梗死患者应用rhTNK-tPA治疗,能够促进冠状动脉造影再通率的提升,且具有一定的安全性。
Objective To discuss the effect of thrombolysis with recombinant human TNK tissue plasminogen activator(rhTNK-tPA)for injection in the treatment of acute ST-segment elevation myocardial infarction.Methods A total of 32 patients with acute ST-segment elevation myocardial infarction were studied and divided into reference group and research group according to different treatment methods,with 16 cases in each group.The control group was treated with urokinase,and the research group was treated with rhTNKtPA.The coronary angiography results of patients with coronary angiography at 90 min after thrombolytic therapy,incidence of endpoint events after thrombolytic therapy,and revascularization rate of patients without coronary angiography at 90 min after thrombolytic therapy were compared between the two groups.Results The recanalization rates of infarct-related vessels(IRA)thrombolysis in myocardial infarction(TIMI)grade 3 and IRA TIMI grade 2-3 in the research group were 83.33%and 91.67%in patients undergoing coronary angiography at 90 min after thrombolytic therapy,which were higher than 38.46%and 46.15%in the reference group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidences of death(within 30 d),target vessel reconstruction,myocardial ischemia recurrence,cardiogenic shock,reinfarction,and other complications between the two groups after thrombolytic therapy(P>0.05).There was no statistically significant difference in the revascularization rate between the two groups of patients without coronary angiography at 90 min after thrombolytic therapy(P>0.05).Conclusion The application of rhTNK-tPA in patients with acute ST-segment elevation myocardial infarction can improve the recanalization rate of coronary angiography with certain safety.
作者
陈培开
CHEN Pei-kai(Sixth People’s Hospital of Nansha District,Guangzhou 511470,China)
出处
《中国现代药物应用》
2022年第3期129-131,共3页
Chinese Journal of Modern Drug Application
