摘要
目的分析葡萄糖转运蛋白1(GLUT1)、氨肽酶P2(XPNPEP2)表达水平与结直肠癌患者预后的关系。方法选取2017年1月至2019年1月于安徽医科大学附属宿州医院胃肠外科就诊且接受手术治疗的84例结直肠癌患者作为研究对象,收集病理组织标本,采用免疫组织化学法检测GLUT1、XPNPEP2的阳性表达,分析GLUT1、XPNPEP2表达与性别、年龄、临床分期、分化程度、浸润深度等临床病理特征的关系。将所有患者根据预后情况分为生存组与死亡组,比较两组患者GLUT1、XPNPEP2的表达及其他可能影响预后的因素,并采用Cox回归分析影响结直肠癌患者预后的相关因素。结果84例结直肠癌患者中,GLUT1的阳性率为71.43%,XPNPEP2的阳性率为72.62%。TNM分期Ⅲ~Ⅳ期患者GLUT1、XPNPEP2表达的阳性率高于TNM分期Ⅰ~Ⅱ期患者(χ^(2)=4.922,P=0.023;χ^(2)=10.142,P=0.001),不同分化程度、浸润深度患者GLUT1、XPNPEP2表达的阳性率比较差异有统计学意义(P<0.05),有淋巴结转移患者GLUT1、XPNPEP2表达的阳性率高于无淋巴结转移患者(P<0.05)。GLUT1、XPNPEP2阳性组与阴性组生存曲线比较差异有统计学意义(P<0.05)。至随访结束时,84例患者中3例失访,失访率为3.57%;81例患者中,59例生存、22例死亡,生存率为72.84%。两组不同TNM分期比较差异有统计学意义(P<0.05),死亡组的淋巴结转移率、GLUT1阳性率、XPNPEP2阳性率均高于生存组(P<0.05)。Cox回归分析结果显示,TNM分期Ⅲ~Ⅳ期、有淋巴结转移、GLUT1阳性、XPNPEP2阳性均是影响结直肠癌患者预后的危险因素(均P<0.01)。结论GLUT1、XPNPEP2的表达与结直肠癌患者部分临床病理特征有关,且是影响患者预后的危险因素,对结直肠癌患者预后具有评估价值。
Objective To analyze the relationship between the expression levels of glucose transporter 1(GLUT1)and aminopeptidase P2(XPNPEP2)and the prognosis of colorectal cancer patients.Methods Eighty-four patients with colorectal cancer who received surgical treatment in the Department of Gastrointestinal Surgery of Suzhou Hospital of Anhui Medical University from Jan.2017 to Jan.2019 were included,and pathological tissue specimens were collected to detect the positive expression of GLUT1 and XPNPEP2 by immunohistochemistry,and the relationship between GLUT1 and XPNPEP2 expression and clinicopathological characteristics such as age,gender,clinical stage,degree of differentiation and depth of infiltration was analyzed.And all the patients were divided into a survival group and a death group according to the prognosis,and the expression of GLUT1,XPNPEP2 and other factors that may affect prognosis were compared between the two groups,and Cox regression was used to analyze the relevant factors affecting the prognosis.Results The rate of GLUT1 positivity was 71.43%and XPNPEP2 positivity was 72.62%in the tissues of the 84 colorectal cancer patients.The positive rates of GLUT1 and XPNPEP2 expression in patients with TNM stageⅢ-Ⅳwere higher than those in patients with TNM stageⅠ-Ⅱ(χ^(2)=4.922,P=0.023;χ^(2)=10.142,P=0.001).The differences in the positive rates of GLUT1 and XPNPEP2 expression in patients with different degrees of differentiation and depth of infiltration were statistically significant(P<0.05),and the positive rates of GLUT1 and XPNPEP2 expression in patients with lymph node metastasis were higher than those in patients without lymph node metastasis(P<0.05).The difference in survival curves between the GLUT1,XPNPEP2 positive group and the negative group was statistically significant(P<0.05).By the end of follow-up,3 out of the 84 patients were lost,with a loss rate of 3.57%;of the 81 patients,59 survived and 22 died,with a survival rate of 72.84%.The difference in different TNM stages between the two grou
作者
梅天明
魏俊
章涛
夏燕
柳长青
MEI Tianming;WEI Jun;ZHANG Tao;XIA Yan;LIU Changqing(Department of Gastrointestinal Surgery,Suzhou Hospital of Anhui Medical University/Suzhou Municipal Hospital,Suzhou 234000,China;Department of Pathology,Suzhou Hospital of Anhui Medical University/Suzhou Municipal Hospital,Suzhou 234000,China)
出处
《医学综述》
CAS
2022年第2期411-416,共6页
Medical Recapitulate
