摘要
以钼酸钠、硫脲、柠檬酸及PEG-400为原料,通过水热法制备纳米MoS_(2),考察了材料的光热转换性能及其对阿霉素(DOX)的负载及控释性能,并探讨了该载药体系对癌细胞的光热-化疗协同治疗作用。结果表明,通过该水热反应体系制备的尺寸约500 nm花球状MoS_(2)纳米材料具有良好的光热转换性能,对DOX的负载率可以达到136.8%,且其释药行为具有pH响应性,pH=5.8时DOX的累积释放量达到70.29%,约为pH=7.4条件下的7倍,表明该材料在药物负载/控释方面具有一定应用价值。此外,负载DOX后的MoS_(2)-DOX的纳米复合物在近红外光照射下对肝癌细胞HuH-7的抑制率高达92.09%,抑制效果明显高于单一的光热治疗和化疗。
Flower-like MoS_(2) nanospheres are prepared via hydrothermal method by using sodium molybdate,thiourea,citric acid and PEG-400 as raw materials.The photothermal conversion performance of MoS_(2) nanospheres is studied,and the loading and controlled release ability of the nanospheres to doxorubicin(DOX)are evaluated.Photothermal-chemotherapy synergistic therapy effect of the drug delivery system on cancer cells is further explored.It is shown that the as-prepared flower-like MoS_(2) nanospheres with a size about 500 nm exhibit excellent photothermal effect.As a carrier,the load rate of the nanospheres to DOX can reach 136.8%,and the drug release behavior shows responsive to pH.As pH=5.8,the cumulative release amount of DOX can reach 70.29%,which is about 7 times of that at pH=7.4,indicating that the material has promising application in drug loading/controlled release.In addition,MoS_(2)-DOX composites under near infrared laser irradiation can reach 92.09%of inhibition rate to HuH-7 liver cancer cells,which is significantly higher than that of photothermal therapy alone or chemotherapy alone.
作者
廉爽
卢淇月
章寅
谢文娟
蒋东丽
LIAN Shuang;LU Qi-yue;ZHANG Yin;XIE Wen-juan;JIANG Dong-li(Pharmacy School,Guilin Medical University,Guilin 541100,China;School of Chemistry and Chemical Engineering,Anhui University of Technology,Maanshan 243002,China)
出处
《现代化工》
CAS
CSCD
北大核心
2022年第1期189-194,共6页
Modern Chemical Industry
基金
桂林医学院博士科研启动基金(31304018001)
大学生创新创业训练计划项目(201910601035)
国家自然科学基金(61971003)。
关键词
二硫化钼
纳米花球
水热合成
载药
光热-化疗协同治疗
molybdenum disulfide
flower-like nanospheres
hydrothermal synthesis
drug loading
synergistic therapy of photothermal and chemotherapy
