摘要
目的:探讨小剂量β受体阻断剂联合伊伐布雷定在慢性心力衰竭患者治疗中的应用。方法:选取2019年8月-2020年8月汕头市澄海区人民医院收治的80例慢性心力衰竭患者为研究对象,按照治疗方式不同分为对照组与研究组,每组40例,患者均给予心力衰竭标准治疗方案,对照组接受小剂量β受体阻断剂治疗,研究组接受小剂量β受体阻断剂+伊伐布雷定治疗,持续治疗4周,评价两组治疗效果,对比两组治疗前后心功能指标、血清脑钠肽(BNP)和炎性细胞因子水平,记录两组治疗期间不良反应。结果:研究组治疗总有效率达90.00%,显著比对照组的70.00%高(P<0.05);治疗前两组心功能指标差异无统计学意义(P>0.05),治疗后两组心功能指标得以显著改善,与对照组比较,研究组LVEF提升更显著,LVESV及LVEDV缩小更显著(P<0.05);治疗前两组BNP和炎性细胞因子水平差异无统计学意义(P>0.05),治疗后与对照组比较,研究组BNP及炎性细胞因子水平下降更显著(P<0.05);研究组不良反应发生率10.00%,与对照组的7.50%比较,差异无统计学意义(P>0.05)。结论:针对慢性心力衰竭患者,小剂量β受体阻断剂联合伊伐布雷定治疗可改善患者心功能,降低机体炎性反应,具有很好的有效性及安全性。
Objective:To explore the effect of small doseβreceptor blocker combined with Ivabradine in the treatment of patients with chronic heart failure.Method:A total of 80 patients with chronic heart failure in Shantou Chenghai District People’s Hospital from August 2019 to August 2020 were selected as the research objects.According to different treatment methods,they were divided into control group and study group,40 cases in each group.All patients were given standard treatment scheme for heart failure,and the control group received small doseβreceptor blocker,the study group was treated with small doseβreceptor blocker combined with Ivabradine.The treatment lasted for 4 weeks.The therapeutic effects of the two groups were evaluated.The cardiac function indexes,serum brain natriuretic peptide(BNP)and inflammatory cytokines levels of the two groups before and after treatment were compared.The adverse reactions of the two groups during treatment were recorded.Result:The total effective rate of the study group was 90.00%,which was significantly higher than 70.00%of the control group(P<0.05).Before treatment,the cardiac function indexes of the two groups had no significant differences(P>0.05),but after treatment,the cardiac function indexes of the two groups were significantly improved,compared with the control group,the LVEF of the study group increased more significantly,and the LVESV and LVEDV decreased more significantly(P<0.05).The levels of BNP and inflammatory cytokines in the two groups had no significant differences before treatment(P>0.05),but the levels of BNP and inflammatory cytokines in the study group decreased more significantly after treatment than the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the study group and the control group(10.00%vs 7.50%,P>0.05).Conclusion:For patients with chronic heart failure,low-doseβreceptor blocker combined with Ivabradine can improve the heart function and reduce the inflammatory reaction of patients,which
作者
杨瑾翀
张传生
王惜彦
YANG Jinchong;ZHANG Chuansheng(Shantou Chenghai District People’s Hospital,Shantou 515800,China)
出处
《中外医学研究》
2022年第3期45-48,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
汕头市科技计划医疗卫生类别项目(200521085263871)。
关键词
Β受体阻断剂
伊伐布雷定
慢性心力衰竭
心功能
脑钠肽
炎性细胞
βreceptor blocker
Ivabradine
Chronic heart failure
Heart function
Brain natriuretic peptide
Inflammatory cells
