摘要
目的探讨沙库巴曲缬沙坦对慢性射血分数中间值心力衰竭(heart failure with mid-range ejection fraction,HFmrEF)患者心功能极其主要标志物的影响。方法选择2018年8月—2020年8月菏泽市曹县第二人民医院收治的慢性HFmrEF患者100例,随机分为对照组和观察组各50例。在心力衰竭转入稳定期后,对照组采用依那普利进行维持治疗,观察组采用沙库巴曲缬沙坦进行维持治疗,比较两组患者治疗1个月后的心功能及其标志物水平。结果治疗1个月后,观察组平均动脉压、中心静脉压和肺毛细血管契压水平低于对照组,差异有统计学意义(P<0.05);而心输出量、心指数和6 min步行距离水平高于对照组,差异有统计学意义(P<0.05)。治疗1个月后,观察组N-末端心房利钠肽、N-末端脑利钠肽、肌钙蛋白I、高敏C反应蛋白、胱抑素-C和脂蛋白相关磷脂酶A2水平均低于对照组,差异有统计学意义(P<0.05)。结论沙库巴曲缬沙坦能够显著提高慢性HFmrEF患者的心功能,并降低心功能标志物水平。
Objective To observe the effect of sakubactrovalsartan on cardiac function and its main markers in patients with chronic HF with mildly reduced ejection fraction(HFmrEF).Methods A total of 100 patients with chronic HFmrEF admitted to our hospital from August 2018 to August 2020 were collected and randomly divided into control group and observation group with 50 patients in each group.After the heart failure turned into a stable stage,the control group was treated with enalapril,while the observation group was treated with sarkubatrivalsartan.The cardiac function and the level of its markers were compared between the two groups after one month of treatment.Results After one month treatment,the levels of MAP,CVP and PCWP in the observation group were significantly lower than those in the control group(P<0.05).The levels of CO,CI and 6MWD were significantly higher than those in the control group(P<0.05).After one month treatment,the levels of NT proANP,NT proBNP,cTnI,Hs CRP,CysC and Lp PLA2 in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Sakubatravalsartan can significantly improve the cardiac function and reduce the level of cardiac function markers in patients with chronic HFmrEF.
作者
杜世国
王秋菊
DU Shiguo;WANG Qiuju(The Second People's Hospital of Cao County,Heze 274412,Shandong Province,China)
出处
《中国实用乡村医生杂志》
2022年第10期63-65,70,共4页
Chinese Practical Journal of Rural Doctor
关键词
心力衰竭
射血分数
中间值
沙库巴曲缬沙坦
心功能
标志物
Heart Failure
Ejection Fraction
Intermediate Value
Shakubatracvalsartan
Cardiac Function
Markers
