摘要
目的:探讨前列地尔联合腺苷蛋氨酸对病毒性肝炎伴高胆红素血症患者肝功能及血液流变性的影响。方法:选取2018年10月-2020年10月荆州市第二人民医院收治92例病毒性肝炎合并高胆红素血症患者,按照随机数字表法将患者分为对照组和观察组,每组46例。两组均行退黄、护肝等常规治疗,对照组给予前列地尔治疗,观察组在对照组基础上联合腺苷蛋氨酸治疗。比较两组肝功能水平[总胆红素(TBil)、谷草转氨酶(AST)及谷丙转氨酶(ALT)]、血液流变性指标、免疫因子[白细胞介素-4(IL-4)、γ-干扰素(INF-γ)]及不良反应发生情况。结果:治疗前,两组AST、TBil、ALT、血细胞比容、红细胞沉降率、血浆黏度及全血黏度比较,差异均无统计学意义(P>0.05);治疗后,两组AST、TBil、ALT、血细胞比容、红细胞沉降率、血浆黏度及全血黏度均低于治疗前,且观察组均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组IL-4、INF-γ比较,差异均无统计学意义(P>0.05);治疗后,两组IL-4均低于治疗前,INF-γ均高于治疗前,且观察组IL-4低于对照组,INF-γ高于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:病毒性肝炎伴高胆红素血症患应用前列地尔联合腺苷蛋氨酸治疗,可增强肝功能水平,改善血液流变性,且免疫功能提升,不良反应较少,具有良好预后。
Objective:To investigate the effect of Alprostadil combined with Ademetionine on liver function and hemorheology in the treatment of viral hepatitis with hyperbilirubinemia.Method:A total of 92 patients with viral hepatitis with hyperbilirubinemia admitted to Jingzhou Second People’s Hospital from October 2018 to October 2020 were selected,they were divided into control group and observation group according to the random number table method,46 cases in each group.Both groups received conventional treatment such as yellow regression and liver protection,the control group received Alprostadil treatment,and the observation group received Ademetionine treatment on the basis of the control group.Liver function levels[total bilirubin (TBil),aspartate aminotransferase (AST) and alanine aminotransferase (ALT)],hemorrheological indexes,immune factors[interleukin-4 (IL-4),γ-interferon (INF-γ)]and the incidence of adverse reactions were compared between two groups.Result:Before treatment,there were no significant differences in AST,TBil,ALT,hematocrit,erythrocyte sedimentation rate,plasma viscosity and whole blood viscosity between two groups (P>0.05);after treatment,AST,TBil,ALT,hematocrit,erythrocyte sedimentation rate,plasma viscosity and whole blood viscosity in both groups were lower than those before treatment,and those in the observation group were lower than those in the control group,the differences were statistically significant (P<0.05).Before treatment,there were no significant differences in IL-4 and INF-γ between two groups (P>0.05);after treatment,IL-4 in both groups were lower than those before treatment,and INF-γ in both groups were higher than those before treatment,and IL-4 in the observation group was lower than that in the control group,and INF-γ in the observation group was higher than that in the control group,the differences were statistically significant (P<0.05).There was no significant difference in the incidence of adverse reactions between two groups (P>0.05).Conclusion:Alprostadil combin
作者
孙娜
SUN Na(Jingzhou Second People’s Hospital,Jingzhou 434000,China)
出处
《中外医学研究》
2022年第2期51-55,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
