摘要
目的:观察熊去氧胆酸、丁二磺酸腺苷蛋氨酸联合治疗妊娠肝内胆汁淤积症(ICP)合并乙型肝炎(HB)的效果及妊娠结局。方法:选取2016年2月—2019年1月本院就诊的ICP合并HB患者100例,分为对照组(42例)给予丁二磺酸腺苷蛋氨酸治疗2周;观察组(58例)给予熊去氧胆酸、丁二磺酸腺苷蛋氨酸联合治疗2周。记录治疗前后瘙痒程度评分,测定相关生化指标,比较两组的临床疗效及妊娠结局。结果:观察组治疗有效率(91.4%)高于对照组(73.8%)(P<0.05);治疗1周、2周后观察组瘙痒评分(1.21±0.37分、1.01±0.29)低于对照组(3.09±0.61分、2.49±0.45分),瘙痒消失时间(4.92±1.03d)、黄疸消失时间(5.47±1.24d)低于对照组(7.10±1.12d、8.21±1.39d),血清肝功能指标水平均低于对照组和治疗前(P<0.05),剖宫产(20.7%)、早产发生率(8.6%)低于对照组(42.9%、23.8%),新生儿体重(3.8±0.7kg)高于对照组(2.9±0.5kg)(P<0.05)。结论:熊去氧胆酸联合丁二酸腺苷蛋氨酸可有效改善ICP合并HB患者瘙痒症状,降低肝功能相关生化指标,改善妊娠结局,具有较好的临床疗效。
Objective:To observe the intervention effects and pregnancy outcomes of ursodeoxycholic acid combined with butane disulfonate ademetionine for treating pregnant women with intrahepatic cholestasis of pregnancy(ICP)and hepatitis B(HB).Methods:100 women with ICP and HB were selected and divided into two groups between February 2016 and January 2019.42 women in the control group were treated with butane disulfonate ademetionine for 2 weeks,and 58 women in the observation group were treated with ursodeoxycholic acid combined with butane disulfonate ademetionine for 2 weeks.The scores of itching degree of the women in the two groups before and after treatment were recorded.The changes of the levels of biochemical indicators,such as serum total bile acid(TBA),alanine aminotransferase(ALT),asparta.recorded.te aminotransferase(AST),total bilirubin(TB)and direct bilirubin(DB),of the women in the two groups before and after treatment were detected.The effect and pregnancy outcomes of the women were compared between the two groups.Results:The effective rate of the women in the observation group(91.4%)was significant higher than that(73.8%)of the women in the control group(P<0.05).After 1 week and 2 weeks of treatment,the itching degree score(1.21±0.37 points and 1.01±0.29 points)of the women in the observation group were significant lower than those(3.09±0.61 points and 2.49±0.45 points)of the women in the control group,the time of itching disappearance(4.92±1.03 d)and the time of jaundice disappearance(5.47±1.24 d)of the women in the observation group were significant shorter than those(7.10±1.12 d and 8.21±1.39 d)of the women in the control group.The serum AST,ALT,TBA,TB and DB levels of the women in the observation group were significant lower than those before treatment and than those of the women in the control group and(P<0.05).The incidences of cesarean section(20.7%)and premature delivery(8.6%)of the women in the observation group were significant lower than those(42.9%and 23.8%)of the women in the control g
作者
李艳娇
李爽
刘正飞
LI Yanjiao;LI Shuang;LIU Zhengfei(The First People's Hospital of Yibin,Sichuan Province,644000)
出处
《中国计划生育学杂志》
2021年第3期488-491,共4页
Chinese Journal of Family Planning
关键词
妊娠肝内胆汁淤积症
乙型肝炎
熊去氧胆酸
丁二磺酸腺苷蛋氨酸
临床效果
Intrahepatic cholestasis of pregnancy
Hepatitis B
Ursodeoxycholic acid
Butane disulfonate ademetionine
Clinical effect
