摘要
目的 探讨熊去氧胆酸联合腺苷蛋氨酸治疗妊娠期肝内胆汁淤积症(ICP)患者的临床效果。方法 66例ICP患者根据用药方式的不同分为两组,单一组给予熊去氧胆酸治疗,联合组给予熊去氧胆酸联合腺苷蛋氨酸治疗,比较两组的治疗效果。结果 联合组的黄疸和瘙痒症状消失时间均短于单一组,治疗后的ALT、 AST、 TBA水平以及不良妊娠结局总发生率均低于单一组(P <0.05)。结论 熊去氧胆酸联合腺苷蛋氨酸可明显缩短ICP患者的症状改善时间,改善其肝功能,减少不良妊娠结局的发生。
Objective To explore the clinical effect of ursodeoxycholic acid combined with adenosylmethionine in the treatment of patients with intrahepatic cholestasis of pregnancy(ICP).Methods 66 patients with ICP were divided into two groups according to different medication methods.The single group was treated with ursodeoxycholic acid,and the combined group was treated with ursodeoxycholic acid combined with adenosylmethionine.The treatment effects of the two groups were compared.Results The disappearance time of jaundice and disappearance time of pruritus in the combined group were shorter than those in the single group,and the levels of ALT,AST and TBA after treatment,and the total incidence of adverse pregnancy outcomes were lower than those in the single group(P<0.05).Conclusions Ursodeoxycholic acid combined with adenosylmethionine can obviously shorten the symptom improvement time of ICP patients,improve their liver function and reduce the occurrence of adverse pregnancy outcomes.
作者
齐朋伟
张玉玲
QI Penguei;ZHANG Yuling(Department of Obste trics,Luoyang Maternal and Child Health Hospital,Luoyang 471000,China)
出处
《临床医学工程》
2024年第8期951-952,共2页
Clinical Medicine & Engineering
关键词
熊去氧胆酸
腺苷蛋氨酸
妊娠期肝内胆汁淤积症
肝功能
妊娠结局
Ursodeoxycholic acid
Adenosylmethionine
Intrahepatic cholestasis of pregnancy
Liver function
Pregnancy outcome
