摘要
目的探讨氨溴索雾化吸入对慢性阻塞性肺疾病合并肺结核患者的治疗效果。方法选取2019年1月至2020年1月于沈阳市第十人民医院就诊的95例慢性阻塞性肺疾病合并肺结核患者作为研究对象,随机分为对照组47例与观察组48例。对照组采用常规对症治疗,观察组采用常规对症联合氨溴索雾化吸入治疗,比较两组治疗效果。结果观察组治疗有效率高于对照组,差异有统计学意义(P<0.05)。与治疗前比较,治疗后两组患者用力肺活量(FVC)、第一秒钟用力呼气容积(FEV_(1))、FEV_(1)/FVC水平升高,且观察组高于对照组,差异有统计学意义(P<0.05)。与治疗前比较,治疗后两组患者血清白细胞介素-6(IL-6)、单核细胞趋化蛋白-1(MCP-1)、肿瘤坏死因子-α(TNF-α)水平降低,且观察组低于对照组,差异有统计学意义(P<0.05)。结论对于慢性阻塞性肺疾病合并肺结核患者在常规对症治疗的基础上,联合氨溴索雾化吸入治疗可获得更加满意的疗效,有利于减轻炎症反应,提高肺功能。
Objective To explore the therapeutic effects of ambroxol atomized inhalation on chronic obstructive pulmonary disease complicated with tuberculosis.Methods From January 2019 to January 2020,a total of 95 patients with chronic obstructive pulmonary disease and pulmonary tuberculosis admitted to The Tenth People’s Hospital of Shenyang City were selected as research subjects and were randomly divided a control group and an observation group,with 47 cases in each group.The control group received conventional symptomatic treatment,and the observation group(n=48)received conventional treatment.Symptomatic+ambroxol nebulized inhalation treatment.The treatment effects of the 2 groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Compared with before treatment,FVC,FEV_(1),FEV_(1)/FVC levels of the 2 groups of patients increased after treatment,and the observation group was higher than the control group,the difference was statistically significant(P<0.05).Compared with before treatment,serum IL-6,MCP-1,and TNF-αlevels of the 2 groups of patients decreased after treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).Conclusion For patients with chronic obstructive pulmonary disease complicated with pulmonary tuberculosis,conventional symptomatic treatment,combined with ambroxol aerosol inhalation therapy can obtain a more satisfactory effect,which is beneficial to reduce inflammation and improve lung function.
作者
孙莹
SUN Ying(Respiratory Department One Ward,The Tenth People's Hospital of Shenyang City,Shenyang 110044,China)
出处
《中国药物经济学》
2021年第12期68-70,74,共4页
China Journal of Pharmaceutical Economics
关键词
氨溴索
雾化吸入
慢性阻塞性肺疾病
肺结核
治疗效果
Ambroxol
Nebulized inhalation
Chronic obstructive pulmonary disease
Tuberculosis
Therapeutic effect
