摘要
目的探讨洛阳地区感染性疾病的病原菌特征,为指导临床合理使用抗菌药物提供科学依据。方法对2018年10月1日—2019年9月30日洛阳地区9家三级医院临床病原微生物检测数据进行回顾性分析。结果分离的细菌总数为12004株,其中革兰阴性菌8459株(70.47%),主要为大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌、鲍曼不动杆菌和阴沟肠杆菌。革兰阳性菌3545株(29.53%),以金黄色葡萄球菌多见。标本大多数来源于痰液、尿液、伤口分泌物和血液。大多数革兰阴性菌对亚胺培南、美洛培南和阿米卡星较敏感;大多数革兰阳性菌对替考拉宁、万古霉素和利奈唑胺敏感,金黄色葡萄球菌对青霉素G的耐药率可达95%。结论洛阳地区的致病菌主要以革兰阴性菌为主,应加强细菌耐药监测,了解细菌耐药现状从而指导临床抗感染治疗。
Objective To explore the characteristics of pathogenic bacteria of infectious diseases in Luoyang area,and to provide scientific basis for guiding the rational use of antibiotics in clinic practice.Methods The clinical pathogenic microorganism detection data of 9 tertiary hospitals in Luoyang area were retrospectively analyzed from October 1,2018 to September 30,2019.Results The total number of isolated bacteria was 12004,of which 8459(70.47%)were gram-negative bacteria,mainly Escherichia coli,Klebsiella pneumoniae,Pseudomonas aeruginosa,Acinetobacter baumannii,and Enterobacter cloacae.There were 3545(29.53%)gram-positive bacteria,mainly Staphylococcus aureus.Most of the specimens were derived from sputum,urine,wound secretions and blood.Most gram-negative bacteria were sensitive to imipenem,meropenem and amikacin;most gram-positive bacteria were sensitive to teicoplanin,vancomycin and linezolid,and the resistance rate of Staphylococcus aureus to penicillin G could reach 95%.Conclusion The pathogenic bacteria in Luoyang area are mainly gram-negative bacteria.Monitoring of bacterial resistance should be strengthened to understand the current status of bacterial resistance to guide clinical anti-infection treatment.
作者
陈众
张瑶
商安全
张伟
谷军星
张亚锋
CHEN Zhong;ZHANG Yao;SHANG An-quan;ZHANG Wei;GU Jun-xing;ZHANG Ya-feng(Department of Clinical Laboratory,Luoyang Hospital of Traditional Chinese Medicine,Luoyang Henan 471000;Tongji Hospital Affiliated Tongji University;Jiaozuo Fifth People’s Hospital,China)
出处
《中国消毒学杂志》
CAS
2022年第1期50-54,共5页
Chinese Journal of Disinfection
基金
中国博士后基金面上项目(2020M681399)。
关键词
病原菌
分布
耐药性
pathogenic bacteria
distribution
drug resistance
