摘要
目的分析2014-2018年天津市宝坻区人民医院感染性疾病病原菌的分布及耐药性,为临床抗菌药物的合理应用提供依据。方法回顾性分析2014-2018年天津市宝坻区人民医院感染性疾病病原菌的分布及耐药性。结果共分离出病原菌13 614株,标本主要来源于痰液、分泌物、尿液、血液,分别占38.10%、19.00%、14.31%、13.41%。革兰阴性杆菌共8 808株,占64.70%,革兰阳性球菌3 796株,占27.88%,革兰阳性杆菌76株,占0.56%;革兰阴性球菌7株,占0.05%,真菌927株,占6.81%。不同部位标本分离的病原菌有所不同。大肠埃希菌、肺炎克雷伯菌对氨苄西林耐药率较高,对美罗培南、亚胺培南、哌拉西林/他唑巴坦、阿米卡星的耐药率低于5%以下;铜绿假单胞菌对头孢唑林、呋喃妥因、复方新诺明、氨苄西林、头孢呋辛钠、头孢曲松的耐药率均在90%以上,对阿米卡星的耐药率在10%以下;鲍曼不动杆菌对阿米卡星耐药率在5%以下,对大部分药物的耐药率较高。金黄色葡萄球菌、表皮葡萄球菌对万古霉素、利奈唑胺、替加环素无耐药,对青霉素、红霉素耐药率较高;肺炎链球菌对克林霉素、红霉素耐药率较高,对万古霉素、利福平无耐药;屎肠球菌对克林霉素、红霉素、青霉素耐药率较高,对替加环素无耐药,对万古霉素、利奈唑胺耐药率为1.98%。结论天津市宝坻区人民医院分离的病原菌对抗菌药物有不同程度的耐药,加强病原学检查及耐药监测有助于临床合理选择抗菌药。
Objective To analyze the distribution and drug resistance of pathogenic bacteria of infectious diseases in Baodi District People’s Hospital of Tianjin from 2014 to 2018, and to provide the basis for rational drug use. Methods The distribution and drug resistance of pathogenic bacteria of infectious diseases in the Baodi District People’s Hospital of Tianjin from 2014 to 2018 were retrospectively analyzed. Results Total 13 614 strains of pathogens were isolated, the specimens mainly came from sputum, secretion, urine, and blood, accounting for 38.10%, 19.00%, 14.31%, and 13.41%, respectively. There were 8 808 strains of Gram-negative bacilli(64.70%). Gram-positive coccus(3 796 strains) accounted for 27.88%, and Gram-positive bacilli(76 strains) accounted for 0.56%, and Gram-negative coccus(7 strains) accounted for 0.05%, and fungi(927 strains) accounted for 6.81%. Pathogenic bacteria isolated from different parts of specimens were different. The drug resistance rate of Escherichia coli and Klebsiella pneumoniae against ampicillin were higher, and against meropenem, imipenem, piperacillin/tazobactam, and amikacin were below 5%. The drug resistance rate of Pseudomonas aeruginosa against cefazolin, furantoin, compound neotamine, ampicillin, cefuroxime sodium, and ceftriaxone were above 90%, and the drug resistance rate against amikacin was below 10%. The drug resistance rate of Acinetobacter baumannii against amikacin was below 5%, and the drug resistance rate against most drugs was higher. Staphylococcus aureus and Staphylococcus epidermidis were sensitive to vancomycin, linezolid, and tegacycline, and the drug resistance rates against penicillin and erythromycin were higher. The drug resistance rate of Streptococcus pneumoniae against clindamycin and erythromycin were higher, and S. pneumoniae was sensitive to vancomycin and rifampicin. The drug resistance rate of Enterococcus faecium against clindamycin, erythromycin and penicillin were higher. E. faecium was sensitive to tegacycline, and the drug resistance r
作者
胡艳杰
苏国发
崔金国
郑大勇
HU Yan-jie;SU Guo-fa;CUI Jin-guo;ZHENG Da -yong(Department of Nosocomial Infection Management, Baodi District People’s Hospital of Tianjin, Tianjin 301800, China;Department of Pharmacy, Baodi District People's Hospital of Tianjin, Tianjin 301800, China;Department of Clincal Laboratory, Baodi District People's Hospital of Tianjin, Tianjin 301800, China)
出处
《现代药物与临床》
CAS
2019年第6期1899-1904,共6页
Drugs & Clinic
关键词
抗菌药物
病原菌
耐药性
antibiotics
pathogens
drug resistance
