摘要
阿尔茨海默病是以进行性认知功能障碍和精神行为异常为特征的神经变性病。睡眠障碍既是阿尔茨海默病的常见临床症状,又是加速疾病进展和认知功能障碍的危险因素,二者存在交互作用。由于目前阿尔茨海默病尚无有效干预靶点,睡眠障碍作为其可控危险因素,早期准确诊断并管理睡眠障碍对延缓阿尔茨海默病进展具有重要作用。本文综述阿尔茨海默病睡眠障碍的临床表现、危险因素、早期筛查及管理,以期从睡眠角度探索阿尔茨海默病治疗的新靶点。
Alzheimer’s disease(AD)is a neurodegenerative disease characterized by progressive cognitive dysfunction and mental behavioral impairment.Sleep disorder is not only a common clinical symptom of AD,but also a risk factor for accelerating the pathological progression of the disease and cognitive impairment.As there is no effective intervention target for AD at present,sleep disorder is a controllable risk factor for AD,and early and correct diagnosis and management of sleep disorder play a key role in delaying the progression of AD.This article reviews the clinical manifestations,risk factors,early screening and management of sleep disorder in AD,in order to explore new therapeutic targets for AD from the perspective of sleep.
作者
唐诗
杜怡峰
TANG Shi;DU Yi-feng(Department of Neurology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Ji'nan 250021,Shandong,China)
出处
《中国现代神经疾病杂志》
CAS
北大核心
2021年第12期1042-1045,共4页
Chinese Journal of Contemporary Neurology and Neurosurgery
基金
国家重点研发计划项目(项目编号:2017YFC1310100)
国家自然科学基金资助项目(项目编号:81861138008)
国家自然科学基金资助项目(项目编号:82011530139)
国家自然科学基金资助项目(项目编号:82001397)
中国科学技术协会青年人才托举工程(项目编号:YESS20200362)
山东省济南市科技计划项目(项目编号:202019187)。
