摘要
创伤性颅脑损伤(TBI)有极高致死率和致残率,进展性出血性损伤(PHI)是TBI常见的并发症,也是TBI患者的主要死因,严重影响着TBI患者的预后。由于肝脏是出血、止血过程中重要的作用器官,TBI后通过多种机制产生对肝脏的损伤,从而在出血机制、凝血活化、纤维溶解方面产生影响,增加延迟性颅内出血事件发生的可能性。肝功能的异常可以在谷丙转氨酶(ALT)、谷草转氨酶(AST)等肝功能检测指标中体现出。故本文通过对颅脑损伤后肝功能损伤相关指标与PHI的相关性进行探讨,判断检测肝功能相关指标是否对TBI后发生PHI有预测价值,有利于在临床工作中作为早期参考以及时发现并积极诊治。
For the high fatality rate and disability rate,traumatic brain injury(TBI)is one of the most dangerous diseases in trauma.The progressive hemorrhagic injury(PHI)should be responsible for the death and poor prognosis of TBI patients,which is the main complication after craniocerebral trauma.Liver plays an important role in the process of hemostasis and hemorrhage.PHI could damage the liver through several mechanisms like hemorrhage,coagulation activation and fibrinolysis,as well as increase the likelihood of delayed intracranial hemorrhage events.Actually,the hepatic dysfunction can be detected by AST,ALT and other liver function indicators.Since the sensitivity of these liver function indicators,we started to explore the association between the liver function indicators and PHI after craniocerebral trauma.Meantime,we will study whether the abnormal liver function indicators could predict the occurrence of PHI,which might be helpful for timely detection and active diagnosis and treatment.
作者
杨玉瑶
胡悦
何松柏
李力卓
Yang Yuyao;Hu Yue;He Songbai;Li Lizhuo(Department of Emergency,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Emergency Department of Chengdu First Hospital,Chengdu 610041,China)
出处
《创伤外科杂志》
2022年第2期150-153,F0003,共5页
Journal of Traumatic Surgery
基金
国家自然科学基金项目(81660329)。
关键词
创伤性脑损伤
进展性出血性损伤
肝功能异常
traumatic brain injury
progressive hemorrhagic injury
hepatic dysfunction
