摘要
目的探讨重型颅脑损伤后继发转氨酶异常与预后关系。方法对117例重型颅脑损伤患者抽血检查谷丙转氨酶(ALT)、谷草转氨酶(AST),按化验结果分为转氨酶升高组和转氨酶正常组。转氨酶升高组包括ALT>50U/L和(或)AST>50U/L。分析两组间GOS预后良好率和死亡率区别;同时比较转氨酶升高组中不同GOS预后评分的ALT、AST水平。结果转氨酶升高组预后良好率低于转氨酶正常组(χ2=4.71,P<0.05),而死亡率高于转氨酶正常组(χ2=5.42,P<0.05)。转氨酶升高组中ALT、AST水平与GOS预后明显相关,且转氨酶水平越高,预后越差。结论重型颅脑损伤常致转氨酶异常,转氨酶升高水平与预后密切相关,监测及保护肝功能有利改善患者预后。
Objective To investigate the relationship between transaminase anomaly and prognosis, in severe brain injury. Methods Total 117 cases with severe traumatic brain injury from January 2010 to June 2012 were admitted and detect the blood level of the alanine transaminase （ALT） and glutamic-oxal（o）acetic transaminase （AST）. Transaminase anomaly included ALT 〉 50 U/L and （or） AST 〉 50 U/L. According to the test results, they were divided into transaminase anomaly group and normal group. The level of ALT, AST and different GOS prognostic score were compared in both groups. Results The favorable prognosis rate in transaminase anomaly group was lower than that of the normal group （X2=4.71, P〈0.05）, with the mortality higher than that of normal group （X2=5.42, P〈0.05）. The level of ALT and AST in transaminase anomaly group was significantly related with GOS prognosis, and the higher transaminase level is, the worse the prognosis. Conclusion Transaminase elevated level are often contributed to severe traumatic brain injury. The careful monitoring and protection of the liver function have a favorable effect on improvement of the prognosis of brain injury patients.
出处
《浙江创伤外科》
2013年第1期7-9,共3页
Zhejiang Journal of Traumatic Surgery
关键词
颅脑损伤
转氨酶
预后
Brain injury
Transaminase
Prognosis
