摘要
背景:间充质干细胞移植在慢性伤口治疗领域中已被证明是一项有前景的新疗法。在增强其应用疗效方面,关于间充质干细胞不同输送途径及优劣比较的研究鲜见报道,优化输送途径对于提高间充质干细胞在创面修复中的应用效果尤为重要。目的:探讨间充质干细胞促进创面修复的相关机制,并就不同移植方式在慢性创面修复中的应用效果展开综述。方法:由第一作者检索中国知网、万方及PubMed数据库中收录的相关文献,中文检索词为"间充质干细胞、机制、移植、途径、慢性创面、伤口、再生、组织工程、皮肤、溃疡",英文检索词为"stem cell/stromal cells/progenitor cell/mesenchymal stem cells,mechanism/therapeutic application,transplantation route/delivery/engraftment/injection/infusion/drug administration routes,wound healing/chronic wound/regeneration/tissue engineering/tissue repair/skin ulcer"。文献检索时间限定在2000年1月至2021年7月,通过阅读文章摘要对文献进行初步筛选,排除与文章主题不相关的文献,纳入的文献数为85篇。结果与结论:(1)旁分泌功能是间充质干细胞发挥创面修复作用的主要机制,间充质干细胞通过分泌可溶性因子和释放胞外囊泡促进血管生成,减轻局部炎症反应,调节细胞外基质重塑,重建利于组织修复的再生微环境。(2)综合来看,生物材料支架是目前间充质干细胞给药途径中最有前景的移植方式之一,与传统全身给药(动脉、静脉给药)和传统局部给药(如皮下、肌内注射)相比,优良的可塑性、生物活性、生物降解性和生物相容性是其占据优势的4个关键特性,以生物材料支架为代表的新型给药方式一定程度上克服了传统给药途径的安全性差、效率低等诸多问题,提高了间充质干细胞在慢性伤口中的应用效果,有待进一步开发其优势。(3)间充质干细胞移植途径的选择一定程度上取决于其治疗目�
of the article,and the literature that was not related to the subject of the article was excluded,and the number of articles finally included was 85 for review.RESULTS AND CONCLUSION:(1)The paracrine function is the main mechanism by which mesenchymal stem cells play the role of wound repair.Mesenchymal stem cells promote angiogenesis by secreting soluble factors and releasing extracellular vesicles,reduce local inflammatory response,regulate the remodeling of extracellular matrix,and rebuild the microenvironment of tissue regeneration.(2)In summary,biomaterial scaffolds are one of the most promising transplantation methods for mesenchymal stem cells.Compared with traditional systemic administration(arterial administration and intravenous administration)and traditional local administration(such as subcutaneous and intramuscular injection),excellent plasticity,bioactivity,biodegradation and biocompatibility are the four key characteristics of their advantages.It overcomes many problems of poor safety and low efficiency of traditional drug delivery routes,which improves the application effect of mesenchymal stem cells in chronic wounds,and its advantages need to be further developed.(3)The choice of transplantation pathway depends on its therapeutic purpose and mechanism to a certain extent.(4)As for the relationship between the action mechanism of mesenchymal stem cells and the route of administration,the homing of mesenchymal stem cells to the damaged tissue was taken as an example.When the transplantation mode of mesenchymal stem cells is local administration(such as intramuscular),in addition to the basic interstitial migration of mesenchymal stem cells in the damaged tissue,the homing and migration of mesenchymal stem cells are not necessary.If the transportation of mesenchymal stem cells is holistic(such as arterial pathway and venous pathway),the homing mechanism of mesenchymal stem cells is necessary to achieve its repair goal.Therefore,to improve the application quality,the route of administration and the
作者
陈贝
张莉
刘毅
桑鹏
金瑛
林苗远
肖乐尧
熊华章
Chen Bei;Zhang Li;Liu Yi;Sang Peng;Jin Ying;Lin Miaoyuan;Xiao Leyao;Xiong Huazhang(Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou Province,China;Discipline Inspection and Supervision Office,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou Province,China;Department of Joint Surgery,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2022年第30期4896-4903,共8页
Chinese Journal of Tissue Engineering Research
基金
遵义市科技支撑计划项目[遵市科合HZ字(2020)218号],项目负责人:桑鹏
贵州省科技计划项目[黔科合支撑[2021]一般434],项目负责人:熊华章。
关键词
间充质干细胞
慢性创面
皮肤
机制
输注途径
移植
组织工程
再生医学
mesenchymal stem cells
chronic wounds
skin
mechanism
infusion route
transplantation
tissue engineering
regenerative medicine
