摘要
目的:通过研究分析盐城地区未成年过敏性疾病患者吸入性过敏原特异性Ig E检测结果分布变化特点,为过敏性疾病预防和临床诊疗提供科学依据。方法:自2020年1月至2021年3月期间,选择430例未成年(<18岁)过敏性疾病患者,血清检测方法采用欧蒙公司生产的过敏原特异性Ig E检测试剂盒。结果:430例患者中,血清过敏原Ig E阳性166例(38.60%),其中尘螨和屋尘是主要的吸入性过敏原。血清Ig E阳性率男性39%,女性36%(P>0.05),中学组女性阳性率(61.11%)高于男性(45.83%)(P<0.05)。不同年龄组间Ig E阳性率有统计学差异(P<0.05),蟑螂、尘螨、霉菌、豚草、屋尘和年龄组间有统计学差异(P<0.05)。不同临床症状与Ig E阳性率有统计学差异(P<0.05),其中呼吸道过敏症状组Ig E阳性率最高(48.30%),不同症状组间主要过敏原都是尘螨。屋尘阳性患者均合并尘螨阳性,其中70.93%的患者表现出了呼吸道过敏症状。结论:尘螨、屋尘是盐城地区未成年过敏性疾病患者最主要的吸入性过敏原,研究血清过敏原分布,对未成年人过敏性疾病的预防、诊疗具有重要意义。
Objective:To study the distribution of inhaled allergen specific Ig E in underage patients with allergic diseases in Yancheng area,and to provide evidence for disease prevention and treatment.Methods:A total of 430 underage(<18 years old)patients with allergic diseases from January 2020 to March 2021 were selected,and their serums were detected by EUROLINE Atopy China(IgE).Results:166(38.60%)were positive for serum allergen Ig E among the 430 underage patients.Dust mites and house dust were the main inhalation allergens.The positive rate of Ig E was 39%in male and 36%in female(P>0.05).The positive rate of female in middle school group(61.11%)was higher than that of male(45.83%)(P<0.05).There was significant difference between age group and Ig E positive rate,and the positive rate increased with age.Cockroaches,dust mites,mould,ragweed,house dust and age groups were statistically different.The positive rate of Ig E was the highest in respiratory allergic symptoms(48.2%),and dust mite was the main allergen among different symptoms.All the patients with positive house dust were positive for dust mites,and 70.93%of them showed respiratory allergic symptoms.Conclusion:Dust mites and house dust are the most important inhaled allergens for patients with allergic diseases in this area.It is of great significance to study the distribution of serum allergens for the prevention,diagnosis and treatment of allergic diseases in minors.
作者
沈鹏
张汉东
张娟
陈晨
崔玉宝
SHEN Peng;ZHANG Han-dong;ZHANG Juan;CHEN Chen;CUI Yu-bao(Department of Clinical Laboratory,The Affiliated Wuxi People's Hospital of Nanjing Medical University,Wuxi,Jiangsu,214023,China;Department of Clinical Laboratory,The Yancheng School of Clinical Medicine of Nanjing Medical University,Yancheng,Jiangsu,224006,China;Laboratory of Pathogenic Microorganism,Yancheng Center for Disease Control and Prevention,Yancheng,Jiangsu,224006,China)
出处
《现代生物医学进展》
CAS
2021年第24期4705-4708,4698,共5页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81971511)。
