摘要
目的探讨本院实施药物治疗临床路径(临床药径)对骨科髋关节置换术围手术期抗菌治疗的影响。方法120例于本院骨科进行髋关节置换术的患者,其中60例在围手术期期间抗菌治疗中实施临床药径的患者作为研究组,60例在围手术期期间抗菌治疗中实施常规干预措施的患者作为对照组。比较两组患者围术期预防使用抗菌药物药的选择、用药时机、使用时间、疗程、费用与住院天数。结果研究组60例(100.00%)术前预防用药按临床药径,使用有循证医学支持的一、二代头孢菌素类,符合《抗菌药物临床用药指导原则》要求,而且术后效果良好。对照组21例(35.00%)药物选择不合理。研究组术前预防使用抗菌药物用药时机为术前0.5~1.0 h的占比93.33%明显高于对照组73.33%,研究组术后术后预防抗菌药物用药疗程≤7 d占比90.00%明显高于对照组的6.67%,差异有统计学意义(P<0.05)。研究组抗菌药物使用时间为(4.08±0.92)d短于对照组的(13.24±1.73)d,抗菌药物费用为(53.89±10.04)元少于对照组的(192.34±33.51)元,住院天数为(7.76±1.41)d短于对照组的(17.58±1.57)d,差异具有统计学意义(P<0.05)。结论对骨科进行髋关节置换术围手术期患者中,实施临床药径,规范临床抗菌药物的使用,能降低患者费用,减轻患者的负担,缩短患者的住院时间。同时临床药径的探索与完善,有利于促进临床药学学科的发展,有利于建立临床合理用药的长效机制,促进药学服务模式转型。
Objective To discuss the effect of clinical pathway of drug therapy in our hospital on the perioperative antibacterial treatment of orthopedic hip replacement in our hospital.Methods A total of 120 patients underwent orthopedic hip replacement,of which 60 patients who implemented clinical pathway of drug therapy during perioperative antibacterial treatment served as the research group,and 60 patients received conventional interventions during perioperative antibacterial treatment served as the control group.The choice of prophylactic use of antibiotics,timing and duration of antibiotics,course of treatment during perioperative period,cost and hospitalization time were compared between the two groups.Results In the research group,60 cases(100.00%)of preoperative prophylaxis were administered according to the clinical pathway of drug therapy,using first-and second-generation cephalosporins with evidence-based medical support,in accordance with the requirements of the"Guidelines for Clinical Use of Antimicrobial Drugs",and postoperative results were good.In the control group,there were 21 cases(35.00%)with unreasonable drug selection.In the research group,the timing of prophylactic use of antibiotics was 93.33% for 0.5-1.0 h preoperatively,which was significantly higher than 73.33% in the control group,and the percentage of postoperative prophylactic use of antibiotics treatment≤7 d was 90.00%,which was significantly higher than 6.67% in the control group.All the differences were statistically significant(P<0.05).In the research group,the duration of antibiotics treatment(4.08±0.92)d was shorter than(13.24±1.73)d in the control group,the cost of antibiotics(53.89±10.04)yuan was less than(192.34±33.51)yuan in the control group,and the hospitalization time(7.76±1.41)d was shorter than(17.58±1.57)d in the control group.All the differences were statistically significant(P<0.05).Conclusion For perioperative patients undergoing orthopedic hip replacement,the implementation of linical pathway of drug therapy,standa
作者
饶智明
谢志芬
张映娜
黄嘉欣
崔思慧
徐思恩
RAO Zhi-ming;XIE Zhi-fen;ZHANG Ying-na(Pharmacy Department,Zhaoqing Hospital of Traditional Chinese Medicine,Zhaoqing 526500,China)
出处
《中国现代药物应用》
2022年第2期221-223,共3页
Chinese Journal of Modern Drug Application
关键词
药物治疗临床路径
骨科髋关节置换术
围手术期
抗菌治疗
Clinical pathway of drug therapy
Orthopedic hip replacement
Perioperative period
Antibacterial treatment
