摘要
目的探讨心脏超声造影联合血清血小板衍生生长因子-C(PDGF-C)和血管生成素-1(Ang-1)预测冠心病主要心血管不良事件(MACE)的临床价值。方法选取2018年1月至2019年12月在该院就诊的冠心病患者123例作为冠心病组,同期在该院行健康体检的志愿者75例作为对照组。根据冠心病组患者随访1年内是否发生MACE,将其分为MACE组(39例)和非MACE组(84例)。比较冠心病组与对照组、MACE组与非MACE组,以及不同冠状动脉病变支数、狭窄程度冠心病患者造影剂充填速度(β值)、最大微泡数量(A值)、PDGF-C和Ang-1水平。采用受试者工作特征曲线分析各指标预测冠心病患者1年内发生MACE的效能。结果冠心病组β值和A值低于对照组,血清PDGF-C和Ang-1水平高于对照组(P<0.01);MACE组β值和A值明低于非MACE组,血清PDGF-C和Ang-1水平高于非MACE组(P<0.01);不同冠状动脉病变支数和狭窄程度冠心病患者β值、A值、PDGF-C和Ang-1水平比较,差异均有统计意义(P<0.05)。心脏超声参数β值、A值,以及血清PDGF-C和Ang-1水平在预测冠心病发生MACE均有较高的效能,4项联合检测的灵敏度87.2%,特异度为98.8%,曲线下面积(AUC)为0.967。结论心脏超声造影联合血清PDGF-C和Ang-1水平检测在预测冠心病患者1年内发生MACE方面具有较高的诊断效能,值得在临床推广应用。
Objective To investigate the clinical value of cardiac ultrasonic contrast combined with serum plate-derived growth factor C(PDGF-C)and angiogene-1(Ang-1)in predicting the major adverse cardiovascular events(MACE)in patients with coronary heart disease(CHD).Methods A total of 123 CHD patients treated in the hospital from January 2018 to December 2019 were selected as the CHD group,and 75 volunteers who underwent physical examination in the hospital during the same period were selected as the control group.According to the occurrence of MACE within 1 year of follow-up,the CHD group was divided into MACE group(39 cases)and non-MACE group(84 cases).Contrast agent filling speed(βvalue),maximum number of microbubbles(A value),PDGF-C and Ang-1 levels were compared between CHD group and control group,MACE group and non-MACE group,CHD patients with different number of coronary artery lesions and degree of stenosis.The efficacy of each index in predicting the occurrence of MACE within 1 year in patients with CHD was analyzed by using the receiver operating characteristic curve.Results Theβand A values in the CHD group were lower than those in the control group,and the serum PDGF-C and Ang-1 levels were higher than those in the control group(P<0.01).Theβand A values in the MACE group were lower than those in the non-MACE group,the level of PDGF-C and Ang-1 were higher than those in the non-MACE group(P<0.01).There were statistically significant differences in theβvalue,A value,PDGF-C and Ang-1 levels of CHD patients with different number of coronary artery lesions and degree of stenosis(P<0.05).Cardiac ultrasound parametersβvalue,A value,serum PDGF-C and Ang-1 levels had high efficacy in predicting MACE in CHD.The sensitivity,specificity and area under the curve(AUC)of the four combined tests were 87.2%,98.8%and 0.967 respectively.Conclusion Cardiac ultrasonic contrast combined with serum PDGF-C and Ang-1 has high diagnostic efficacy in predicting the occurrence of MACE in patients with CHD within 1 year,which is wort
作者
汤卫忠
唐群力
翟大明
TANG Weizhong;TANG Qunli;ZHAI Daming(Department of Ultrasound Medicine,Central Hospital of Fengxian District,Shanghai 201400,China)
出处
《检验医学与临床》
CAS
2022年第3期333-337,共5页
Laboratory Medicine and Clinic
