摘要
目的研究脑干卒中后低氧血症患者单胺类递质变化情况与卒中后睡眠障碍的相关性。方法回顾性分析我院2018年5月至2021年1月收治的53例脑干卒中后低氧血症患者血浆单胺类递质及多导睡眠图与健康对照组的临床资料,进行研究组单胺类神经递质与睡眠参数相关性分析。结果研究组血清中去甲肾上腺素(NE)、多巴胺(DA)、5-羟吲哚乙酸(5-HIAA)、5-羟色胺(5-HT)低于对照组,差异有统计学意义(P<0.05);研究组睡眠潜伏期(SL)长于对照组,快速动眼期(REMT)短于对照组,及REM潜伏期百分比(REML)低于对照组,差异有统计学意义(P<0.05);去甲肾上腺素(NE)和5-羟色胺(5-HT)与睡眠障碍呈正相关。结论脑干卒中后低氧血症患者单胺类神经递质降低,患者睡眠障碍情况与单胺类神经递质变化具有相关性。
Objective To study the correlation between the changes of monoamine neurotransmitters and sleep disorders after stroke in patients with hypoxemia after brainstem stroke.Methods The clinical data of plasma monoamine transmitters and polysomnography in 53 patients with hypoxemia after brainstem stroke admitted to our hospital from May 2018 to January 2021 and healthy controls were retrospectively analyzed.The correlation between monoamine neurotransmitters and sleep parameters was analyzed.Results The serum norepinephrine(NE),dopamine(DA),5-hydroxyindoleacetic acid(5-HIAA),and serotonin(5-HT)in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The sleep latency(SL)in the study group was longer than that in the control group.The rapid eye movement(REMT)in the study group was shorter than that in the control group,and REM latency percentage(REML)in the study group were lower than those in the control group,with statistical significance(P<0.05).Norepinephrine(NE)and serotonin(5-HT)showed a positive correlation with sleep disorders.Conclusion Monoamine neurotransmitters are decreased in patients with hypoxemia after brainstem stroke,and sleep disturbance is correlated with monoamine neurotransmitter changes.
作者
李巍峰
张晓钰
LI Weifeng;ZHANG Xiaoyu(Department of Neurology,People′s Hospital of Rongcheng in Shandong Province,Rongcheng 264300,China;Department of Neurology,Capital Medical University School of Rehabilitation Medicine,Beijing Bo′ai Hospital,China Rehabilitation Research Center,Beijing 100068,China)
出处
《中国现代医生》
2021年第36期45-48,共4页
China Modern Doctor
关键词
脑干卒中
低血氧症
单胺类递质
睡眠
Brainstem stroke
Hypoxemia
Monoamine transmitters
Sleep
