摘要
目的系统评价叉头框蛋白M1(FoxM1)在宫颈癌组织中的表达及其与临床病理特征的关系。方法计算机检索PubMed、CBM、Cochrane Library、万方、知网、维普等数据库,收集已公开发表的关于宫颈癌组织中FoxM1蛋白表达及其临床病理特征相关的病例随机对照研究,时间为建库起至2020年7月。根据纳入和排除标准筛选文献,应用RevMan5.3软件进行meta分析。结果最终纳入19篇文献,共2781例受试者,其中宫颈癌患者1446例,宫颈上皮内瘤变(CIN)患者403例,正常宫颈妇女932例。meta分析结果显示:宫颈癌组中FoxM1蛋白表达明显高于正常宫颈组和CIN组,差异均有统计学意义(P<0.001);CIN组的FoxM1蛋白表达明显高于正常宫颈组,差异有统计学意义(P<0.001);FoxM1蛋白高表达与更高淋巴结转移率(P<0.001)、更低分化程度(P<0.001)和更深肌层浸润(P<0.001)有关,而与年龄(P=0.150)和病理类型(鳞癌或腺癌,P=0.290)无关。结论FoxM1蛋白参与宫颈癌的发生、发展,可以作为预测宫颈肿瘤进展的有效标志及宫颈癌治疗的有效靶点。
Objective To systematically evaluate the expression of FoxM1 protein in cervical cancer tissue and its relationship with clinicopathological characteristics.Methods The databases of PubMed,CBM,Cochrane Library,Wanfang,CNKI and VIP were retrieved by computer to collect the related randomized controlled trials on the FoxM1 protein expression in cervical cancer tissue and clinicopathological features.The search date was from database establishment to July 2020 and the literatures were selected according to the inclusion and exclusion criteria.The RevMan5.3 software was applied to conduct the meta analysis.Results Nineteen articles were finally included,with a total of 2781 subjects,including 1446 cases of cervical cancer,403 cases of cervical intraepithelial neoplasia(CIN),and 932 women with normal cervix.The meta analysis results showed that the expression of FoxM1 protein in the cervical cancer group was significantly higher than that in the normal cervical group and CIN group,and the differences were statistically significant(P<0.001);the FoxM1 protein high expression was associated with higher metastasis rates of lymph node(P<0.001),lower differentiation degree(P<0.001)and the invasion of deeper depth muscle(P<0.001),but had no relation with the age(P=0.150)and pathological type(squamous cell carcinoma or adneocarcinoma,P=0.290).Conclusion The FoxM1 protein is participated in the occurrence and development of cervical cancer,and may serve an effective marker for predicting the progress of cervical tumor and an useful target spot for the treatment of cervical cancer.
作者
李丽红
沐超
王婷
袁炜
姚运红
胡新荣
LI Lihong;MU Chao;WANG Ting;YUAN Wei;YAO Yunhong;HU Xinrong(School of Medical Technology,Guangdong Medical University,Dongguan,Guangdong 523808,China;College of Basic Medical,Guangdong Medical University,Dongguan,Guangdong 523808,China)
出处
《重庆医学》
CAS
2022年第2期301-306,共6页
Chongqing medicine
基金
国家自然科学基金项目(81572566)。
