摘要
[目的]挖掘高祥福教授治疗系统性红斑狼疮(systemic lupus erythematosus,SLE)的选方用药规律。[方法]收集2017年7月1日至2020年6月30日高祥福教授门诊就诊的SLE患者资料,构建方剂数据库,对药物的累计频数、药物类别及性味等进行描述性分析,提取出频数最高的50种药物,并进行系统聚类分析以及关联规则分析。[结果]符合纳入标准的诊次共630次,其中涉及中药181味,使用频数最多的前5项为生地黄、青蒿、丹参、金樱子、芡实。累计用药20大类,清热药、补虚药、活血化瘀药、收涩药位居前四。使用频数最高的药性药味是寒性、甘味。系统聚类分析得出了7组药物组合及9种单药,涉及青蒿鳖甲汤、水陆二仙丹、犀角地黄汤等方剂。关联规则分析获得二项关联组合74项,涉及金樱子与芡实、鳖甲与青蒿、牡丹皮与生地黄等药对;三项关联组合97项,涉及清热药+收涩药、收涩药+活血药、清热药+补虚药等配伍。[结论]高祥福教授治疗SLE以养阴清热、滋补肝肾为核心,并随证搭配活血化瘀、凉血解毒、补益肺脾、温肾利水、祛风通络之品,用药善于甘、苦、辛配伍。
[Objective] To explore the rule of prescription selection of Professor GAO Xiangfu in the treatment of systemic lupus erythematosus(SLE).[Methods] From July 1, 2017 to June 30, 2020, the patients with SLE in Professor GAO Xiangfu’s outpatient clinic were collected, the prescription database was constructed. Descriptive analysis was conducted on the cumulative frequency,the category, the nature and flavor of Chinese herbs, and systematic cluster analysis and association rule analysis were conducted on the 50 herbs used most frequently. [Results] Among 630 visits included according to the criteria, 181 kinds of Chinese herbs were involved, and the top five items were Rehmannia Glutinosa, Artemisia Annua,SalviaeMiltiorrhiza, Rosa Laevigata and Gordon Euryale. Accumulatively, 20 categories of Chinese herbs were used, including heat-clearing herbs,deficiency-supplementing herbs, herbs for promoting blood circulation and removing blood stasis, and astringent herbs. Cold nature and sweet flavor were the most frequently used.Systematic cluster analysis obtained 7 groups of herb combinations and 9 kinds of single herb, including formulas such as Qinghao Biejia decoction, Shuilu Erxian capsule and Xijiao Dihuang decoction, etc. In the analysis of association rules, a total of 74 two-herb combinations were obtained, which involved herb pairs of Rosa Laevigata and Gordon Euryale, AmydaeCarapax and Artemisia Annua, Cortexmoutan and Rehmannia Glutinosa, etc. There were 97 items of three-herb combinations, involving the compatibility of heat-clearing herbs and astringent herbs,astringent herbs and those for promoting blood circulation, heat-clearing herbs and deficiency-supplementing herbs. [Conclusion] The core of Professor GAO Xiangfu’s treatment of SLE is to nourish Yin and clear heat, nourish the liver and kidney, combined with herbs of promoting blood circulation and removing blood stasis, cooling blood and detoxify, tonifying the lung and spleen, warming the kidney and promoting diuresis, dispelling wind and clearing
作者
黄昊
席梦丹
高祥福
HUANG Hao;XI Mengdan;GAO Xiangfu(The First Clinical Medical School of Zhejiang Chinese Medical University,Hangzhou(310053),China;The First Affiliated Hospital of Zhejiang Chinese Medical University)
出处
《浙江中医药大学学报》
CAS
2021年第12期1325-1330,共6页
Journal of Zhejiang Chinese Medical University
关键词
系统性红斑狼疮
医案研究
名中医
临床经验
数据挖掘
用药规律
辨证论治
高祥福
systemic lupus erythematosus
medical case study
famous Chinese medicine practitioner
clinical experience
data mining
medication rule
syndrome differentiation and treatment
GAO Xiangfu
