摘要
目的:使用光学相干断层血流成像技术(OCTA)评估重度非增殖性糖尿病视网膜病变(S-NPDR)患者和健康受试者黄斑区血管网的区别以及S-NPDR患者全视网膜激光光凝(PRP)前后指标的变化。方法:前瞻性研究。共纳入18例31眼S-NPDR患者和健康受试者31眼。使用OCTA检测黄斑血流密度以及中心凹无血管区(FAZ)的面积和体积。结果:与正常对照组相比,S-NPDR患者的浅层视网膜毛细血管丛(SCP)中,除了中心凹血流密度外其余的黄斑区血流密度均下降。在深层视网膜毛细血管丛(DCP)中,S-NPDR患者的黄斑血流密度也有所下降。此外,S-NPDR患者FAZ面积和体积扩大。S-NPDR患者接受PRP 6mo后,中心凹SCP和DCP密度明显增加,而FAZ面积和体积缩小。接受PRP 3mo后,只有中心凹的DCP增加。S-NPDR患者接受PRP 1mo后,中心凹SCP和DCP密度以及FAZ面积和体积的变化比较无差异。结论:OCTA检测显示S-NPDR患者的黄斑毛细血管网受损。尽管OCTA的这些指标在S-NPDR患者接受PRP 1、3mo后没有明显变化,但是在6mo的随访后这些指标发生变化,在临床上具有参考意义。
AIM:To evaluate the differences of macular vascular network measured by optical coherence tomography angiography(OCTA)between severe non-proliferative diabetic retinopathy(S-NPDR)eyes and health eyes,and explore the changes of these OCTA characteristics in patients with S-NPDR before and after panretinal photocoagulation(PRP).METHODS:This was a prospective study including 31 eyes from 18 consecutive patients with S-NPDR and 31 eyes of healthy subjects.We measured macular vascular density and foveal avascular zone(FAZ)area and volume by an OCTA device.RESULTS:Compared to the normal control group,in superficial retinal capillary plexus(SCP),macular vascular density decreased in S-NPDR group,except foveal vascular density unchanged.Consistently,in deep retinal capillary plexus(DCP),macular vascular density was also lower in S-NPDR group.In addition,FAZ area and volume expanded in S-NPDR eyes.At 6mo post-PRP in S-NPDR eyes,foveal SCP and DCP densities increased significantly,while FAZ area and volume decreased.At 3mo post-PRP,only foveal vascular density in DCP increased.The changes of foveal SCP and DCP densities as well as FAZ area and volume were not statically significant at 1mo post-PRP.CONCLUSION:Macular vascular network was impaired in S-NPDR assessed by OCTA.Although OCTA parameters were not significantly affected by PRP in 1 and 3mo period,at 6mo follow-up parameters became significant after PRP.
作者
邱奥望
袁冬青
朱鸿静
顾晨烽
刘庆淮
张薇玮
Ao-Wang Qiu;Dong-Qing Yuan;Hong-Jing Zhu;Chen-Feng Gu;Qing-Huai Liu;Wei-Wei Zhang(Department of Ophthalmology,the First Affiliated Hospital of Nanjing Medical University(Jiangsu Province Hospital),Nanjing 210029,Jiangsu Province,China)
出处
《国际眼科杂志》
CAS
北大核心
2022年第2期175-181,共7页
International Eye Science
