摘要
目的探究高血压冠心病应用氨氯地平阿托伐他汀钙片(ABAACT)的疗效及作用。方法方便选择2019年1月—2020年12月接诊的1000例高血压冠心病患者,随机分为观察组(500例,行ABAACT治疗)和对照组(500例,行苯磺酸氨氯地平治疗)。评价组间血液流变学指标[血浆黏度(PV)、红细胞压积(HCT)、细胞沉降率(ESR)]、血脂[血清低密度脂蛋白(LDL-C)、三酰甘油(TG)、总胆固醇(TC)]及血压指标[舒张压(DBP)、收缩压(SBP)]、血清血管活性肽(Salusin-β)、G蛋白耦联受体配体(Apelin)、同型半胱氨酸(Hcy)和临床有效率。结果治疗6个月后,与对照组对比,观察组PV(1.38±0.26)MPa·s、HCT(26.78±2.98)%、ESR(16.72±3.68)mm/h、LDL-C(2.01±0.26)mmol/L、TG(1.33±0.22)mmol/L、TC(3.78±0.63)mmol/L、DBP(81.46±4.12)mmHg、SBP(125.24±5.43)mmHg、Salusin-β(3.73±0.35)mmol/L、Apelin(1.53±0.11)μg/L、Hcy(5.57±1.23)mmol/L均较低,差异有统计学意义(t=26.574、23.187、14.895、26.334、19.476、15.777、23.819、21.728、21.778、36.421、19.326,P<0.05);治疗6个月后,观察组临床有效率(96.00%)优于对照组(93.00%),差异有统计学意义(χ^(2)=4.329,P<0.05)。结论对高血压冠心病患者行ABAACT治疗,能增强血压控制效果,调节血脂、Salusin-β、Apelin、Hcy水平,改善血液流变学,疗效显著,值得推广。
Objective To explore the efficacy and effect of amlodipine and atorvastatin calcium tablets(ABAACT)in hypertensive coronary heart disease.Methods Conveniently selected 1000 patients with hypertension and coronary heart disease admitted from January 2019 to December 2020,and randomly divided them into observation group(500 cases,received ABAACT treatment)and control group(500 cases,received benzenesulfonic acid Amlodipine treatment).Evaluated the hemorheological indicators between groups[plasma viscosity(PV),hematocrit(HCT),cell sedimentation rate(ESR)],blood lipids[serum low-density lipoprotein(LDL-C),glycerol Triester(TG),total cholesterol(TC)]and blood pressure indicators[diastolic blood pressure(DBP),systolic blood pressure(SBP)],serum vasoactive peptide(Salusin-β),G protein-coupled receptor ligand(Apelin),Homocysteine(Hcy),and clinically effective rate.Results After 6 months of treatment,compared with the control group,the observation group had PV(1.38±0.26)MPa·s,HCT(26.78±2.98)%,ESR(16.72±3.68)mm/h,LDL-C(2.01±0.26)mmol/L,TG(1.33±0.22)mmol/L,TC(3.78±0.63)mmol/L,DBP(81.46±4.12)mmHg,SBP(125.24±5.43)mmHg,Salusin-β(3.73±0.35)mmol/L,Apelin(1.53±0.11)μg/L,Hcy(5.57±1.23)mmol/L,all low,the difference was statistically significant(t=26.574,23.187,14.895,26.334,19.476,15.777,23.819,21.728,21.778,36.421,19.326,P<0.05);after 6 months of treatment,the clinical effective rate of the observation group(96.00%)was better than that of the control group(93.00%),the difference was statistically significant(χ^(2)=4.329,P<0.05).Conclusion ABAACT treatment for patients with hypertension and coronary heart disease can enhance the effect of blood pressure control,regulate blood lipids,Salusin-β,Apelin,and Hcy levels,and improve blood rheology.The effect is significant and it is worthy of promotion.
作者
陈明菜
CHEN Mingcai(Department of Pharmacy,the Second Affiliated Hospital of Xiamen Medical College,Xiamen,Fujian Province,361021 China)
出处
《中外医疗》
2021年第34期103-106,共4页
China & Foreign Medical Treatment
关键词
氨氯地平阿托伐他汀钙片
高血压
冠心病
作用
Amlodipine and atorvastatin calcium tablets
Hypertension
Coronary heart disease
Effect
