摘要
目的研究儿童矮小症产生的原因及相关的预防干预措施。方法对2020年1月—2021年5月该院门诊及住院部收治的382例矮小症患儿临床诊断资料进行回顾性分析,总结其发生儿童矮小症的原因,并以此为依据分析该疾病的相关预防干预措施。结果对382例矮小症患儿发病原因进行分析后可见,较常见病因所占比例如下:20.16%为生长激素神经分泌功能障碍(GHND),18.59%为特发性矮小,6.28%为体质性青春期发育迟缓,12.04%为宫内发育迟缓,6.02%为营养缺乏所致发育迟缓,8.64%为特发性早熟,7.07%为Turner综合征(TS),9.16%为小儿唐氏综合征,6.54%为原发性甲状腺功能减低症,4.71%为软骨发育不良。各类病因中,GHND、特发性矮小所占比例较高,差异有统计学意义(P<0.05)。从患儿年龄段来看,≤6岁的93例患儿主要发病原因为宫内发育迟缓(34.41%)、小儿唐氏综合征(33.33%)及营养缺乏所致发育迟缓(20.43%);7~12岁的201例患儿主要发病原因为GHND(27.86%)、特发性矮小(33.33%)、TS(9.95%)、特发性早熟(7.46%)、原发性甲状腺功能减低症(9.45%);≥13岁的88例患儿主要发病原因为GHND(19.32%)、体质性青春期发育迟缓(17.05%)、特发性早熟(19.32%)、软骨发育不良(18.18%)。结论儿童矮小症的致病因素较复杂,各类病因中以GHND及特发性矮小最为常见;针对以上情况,临床应全面采集患儿病史并评估其发育情况,完善相关实验室检查以进一步明确矮小症发病原因。
Objective To study the causes of short stature in children and related preventive intervention measures.Methods The clinical diagnosis data of 382 children with short stature admitted to the outpatient and inpatient departments of the hospital from January 2020 to May 2021 were retrospectively analyzed,and the reasons for the occurrence of childhood short stature were summarized,and used this as a basis to analyze the relevant prevention and intervention measures of the disease.Results After analyzing the causes of short stature in 382 children with short stature,it can be seen that the more common causes were as follows:20.16%were growth hormone neurosecretion dysfunction(GHND),18.59%were idiopathic short stature,and 6.28%were constitutionally retarded puberty,12.04%were intrauterine growth retardation,6.02%were growth retardation caused by nutritional deficiency,8.64%were idiopathic precocious puberty,7.07%were Turner syndrome(TS),9.16%were Down syndrome in children,6.54%were primary hypothyroidism,and 4.71%were achondroplasia.Among the various causes,GHND and idiopathic short stature accounted for a higher proportion,the difference was statistically significant(P<0.05).From the perspective of the age of the children,the main causes of the 93 children≤6 years old of age were intrauterine growth retardation(34.41%),pediatric Down syndrome(33.33%)and growth retardation due to nutritional deficiency(20.43%);the main causes of 201 children aged 7-12 years old were GHND(27.86%),idiopathic short stature(33.33%),TS(9.95%),idiopathic precocious puberty(7.46%),and primary hypothyroidism(9.45%);88 cases of children≥13 years old of age were mainly caused by GHND(19.32%),constitutional puberty retardation(17.05%),idiopathic precocious puberty(19.32%),and achondroplasia(18.18%).Conclusion The pathogenic factors of children's short stature are more complicated.Among the various causes,GHND and idiopathic short stature are the most common.In view of the above situation,clinical history of children should be comprehensivel
作者
严红
YAN Hong(Department of Pediatrics,Maternal and Child Health Hospital of Nanping City,Nanping,Fujian Province,353000 China)
出处
《中外医疗》
2021年第34期91-94,共4页
China & Foreign Medical Treatment
关键词
儿童矮小症
致病因素
预防
Short stature in children
Pathogenic factors
Prevention
