摘要
骨稳态是破骨细胞和成骨细胞共同作用的过程。骨组织中存在大量的细胞外基质蛋白。在蛋白合成过程中,未折叠及错误折叠蛋白增多导致内质网应激,诱发肌醇必需酶1α(IRE1α)、内质网膜蛋白激酶(PERK)和活化转录因子6(ATF6)家族介导的非折叠蛋白应答。当过度应激时将造成软骨发育不良、骨关节炎和牙周炎骨吸收等疾病。本文就近年内质网应激在骨代谢中作用的研究进展做一综述,有助于进一步了解内质网应激在骨代谢及治疗相关疾病中的作用及意义。
Bone homeostasis is a process of interaction between osteoclasts and osteoblasts,with abundant extracellular matrix proteins existing in bone tissue. During protein synthesis,the increase of unfolded and misfolded proteins lead to endoplasmic reticulum stress,which induce the unfolded protein responses mediated by IRE1α,PERK and ATF6 family.Excessive stress leads to chondrodysplasia,osteoarthritis and periodontitis bone resorption. This review focuses on the role of endoplasmic reticulum stress in bone metabolism and it is of great significance for our further understanding of bone metabolism and treatment of related diseases.
作者
林锐钿
李子涵
古丽莎
Lin Ruitian;Li Zihan;Gu Lisha(Hospital of Stomatology,Guanghua School of Stomatology,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Stomatology,Guangzhou 510055,China)
出处
《中华口腔医学研究杂志（电子版）》
CAS
2021年第5期309-313,共5页
Chinese Journal of Stomatological Research(Electronic Edition)
基金
国家自然科学基金(81873712)
广州市科技计划(201904010057)。
关键词
内质网应激
非折叠蛋白应答
细胞凋亡
骨代谢
Endoplasmic reticulum stress
Unfolded protein response
Apoptosis
Bone metabolism
