摘要
癌症的发病率和死亡率不断上升,已成为威胁全球人类健康的首要危险因素,癌症的防治一直是困扰世界各国学者的难题,由于化疗药物有较强的不良反应,严重影响癌症患者的生活质量。因此,寻找安全有效且毒不良反应小的抗癌药物已迫在眉睫。近年来,传统药物的抗癌作用备受关注,随着医疗科研水平的发展,越来越多的抗癌活性成分从传统药物中提取出来,且不良反应较低,抗癌效果良好。芸香苷是一种独特的类黄酮,存在于许多植物中。研究发现芸香苷能抑制乳腺癌、结肠癌、肺癌、前列腺癌等肿瘤细胞的增殖。此外,已有报道芸香苷单独或与其他治疗药物联合可调节多种信号通路及各种炎症、凋亡、自噬和血管生成等信号介质,从而抑制肿瘤进展,而且芸香苷还能降低肿瘤耐药性和化疗药物的不良反应。尽管其具有强大的抗癌潜力,但生物利用度低、溶解度低等因素限制了其直接使用,而围绕芸香苷制备的纳米制剂可提高其作为抗癌成分的生物利用度和功效。目前对于芸香苷的抗癌潜力及在各类癌症中相关分子靶点的综合和分析略有缺乏,所以笔者检索了近年来关于芸香苷抗癌作用的文献,综述了其抗癌机制和分子靶点,并讨论了相关的药物递送及安全问题,为芸香苷的进一步开发和应用提供新的思路和理论基础。
The morbidity and mortality of cancer have been on the rise,making it atop the list of human health threats.It has been a conundrum of global magnitude.As the side effects of chemotherapeutics seriously affect the life quality of cancer patients,it is urgent to find effective anti-cancer drugs with small toxic and side effects.In recent years,the anti-cancer effects of traditional Chinese medicine have attracted the interest of scholars.Owing to the improvement of medical research,an increasing number of anti-cancer components with small toxic and side effects have been extracted from traditional Chinese medicine.Rutin,a unique flavonoid in Chinese medicinals and many plants,proves to inhibit the proliferation of breast cancer,colon cancer,lung cancer,and prostate cancer cells.In addition,rutin alone or in combination with other therapeutic drugs can regulate a variety of signaling pathways and signal mediators of inflammation,apoptosis,autophagy,and angiogenesis,thereby suppressing tumor progression.Moreover,it can also alleviate the drug resistance of tumors and the side effect of chemotherapeutics.Nevertheless,it is limited by the low bioavailability and low solubility,to which nano delivery system turns to be a solution.At the moment,the anti-cancer potential of rutin and the molecular targets of it against various cancers have not been summarized and comprehensively analyzed.Therefore,the authors retrieved articles on the anti-cancer effects of rutin in recent years,summed up the mechanisms and molecular targets,and discussed relevant drug delivery systems and the safety,aiming at laying a theoretical foundation for further development and application of the flavonoid.
作者
牟悦
王彤
王雪振
张亚楠
MOU Yue;WANG Tong;WANG Xue-zhen;ZHANG Ya-nan(Shandong University of Traditional Chinese Medicine,Jinan 250355,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2022年第2期249-256,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81703839)
山东省自然科学基金重大基础研究项目(ZR2019ZD23)。
关键词
芸香苷
肿瘤
抗癌活性
作用机制
rutin
tumor
anti-cancer activity
action mechanism
