摘要
青少年局限性硬皮病(juvenile localized scleroderma,JLS)是一种罕见的儿童自身免疫性疾病,早期缺乏特异性症状,易被误诊、漏诊而导致病变加剧,甚至造成机体功能损害和生长障碍等严重后果。为明确JLS病因,指导有效治疗药物的开发和应用,本文综述近年来JLS发病机制相关学说,总结其传统治疗方案和相关新型治疗药物研究进展,以提高临床医生对JLS的认识。
Juvenile localized scleroderma(JLS)is a rare autoimmune disease in children.The lack of specificity in the early symptoms of JLS makes it easy to be misdiagnosed and missed,which leads to the continuous progression of the lesions,and even causes systemic malfunction and growth disorder.For identifying the etiology of JLS and guiding the development and application of effective therapeutic drugs,we reviewed recent theories about the pathogenesis of JLS and summarized the traditional treatment options and relevant new therapeutic drugs,aiming to further enhance the fundamental understanding of JLS and its therapeutic progress.
作者
杨婧懿
徐倩玥
余红
YANG Jingyi;XU Qianyue;YU Hong(Department of Dermatology,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China)
出处
《协和医学杂志》
CSCD
2022年第1期110-116,共7页
Medical Journal of Peking Union Medical College Hospital
关键词
青少年局限性硬皮病
发病机制
治疗
研究进展
juvenile localized scleroderma
pathogenesis
treatment
research progress
