摘要
目的探讨中性粒细胞CD64(neutrophil CD64,nCD64)联合降钙素原(procalcitonin,PCT)与慢加急性肝衰竭(acute-on-chronic liver failure,ACLF)患者抗感染能力的相关性。方法选取2019年1月至2020年12月珠海市人民医院收治的ACLF患者80例,随机分为感染组和非感染组,各40例。根据治疗效果,将感染组分为三个亚组:高危组、中危组、低危组。采集患者静脉血,检测血清中nCD64、PCT水平,绘制受试者操作特征曲线(receiver operating characteristic,ROC),并计算ROC曲线下面积(area under the curve,AUC)。结果两组患者性别、年龄等一般资料比较,差异无统计学意义(P>0.05);感染组nCD64、PCT水平均高于非感染组(P<0.01);高危组患者nCD64、PCT水平为(83.56±16.48)%、(3.65±2.43)ng/mL,明显高于中危组[(75.63±17.54)%、(2.28±2.03)ng/mL]和低危组[(70.44±14.29)%、(0.82±0.02)ng/mL],差异显著(P<0.01);nCD64、PCT及nCD64联合PCT的AUC分别为0.9212(95%CI:0.861~0.982)、0.9125(95%CI:0.835~0.990)、0.9731(95%CI:0.876~0.994),三者均大于0.9。其中,nCD64联合PCT的AUC高于单项nCD64、PCT。结论nCD64、PCT水平与ACLF患者抗感染能力密切相关,且nCD64联合PCT的诊断效能高于单项nCD64、PCT,可用于评估ACLF患者感染疾病的严重程度。
Objective To explore the correlation between neutrophil CD64(nCD64)in combined with procalcitonin(PCT)and anti-infection ability of patients with acute-on-chronic liver failure(ACLF).Methods Eighty patients with ACLF admitted to Zhuhai People’s Hospital from 2019 to 2020 were randomly divided into infection group and non-infection group,with 40 cases in each group.According to the treatment effect,the infection group was divided into three subgroups:high risk group,medium risk group and low risk group.The venous blood of patients was collected,and the levels of nCD64 and PCT in serum were detected.The receiver operating characteristic curve(ROC)was drawn and the area under the curve(AUC)was calculated.Results There was no significant difference in general data such as gender and age between the two groups(P>0.05).The levels of nCD64 and PCT in infected group were higher than those in non-infected group(P<0.01).The levels of nCD64 and PCT in high-risk group were(83.56±16.48)%and(3.65±2.43)ng/mL,which were significantly higher than those in middle-risk group[(75.63±17.54)%,(2.28±2.03)ng/mL]and low-risk group[(70.44±14.29)%,(0.82±0.02)ng/mL];the AUC of nCD64,PCT and nCD64 combined PCT were 0.9212(95%CI 0.861-0.982),0.9125(95%CI 0.835-0.990)and 0.9731(95%CI 0.876-0.994),respectively,all of which were greater than 0.9.The AUC of nCD64 combined with PCT was higher than that of nCD64 and PCT alone.Conclusion The levels of nCD64 and PCT are closely related to the anti-infection ability of ACLF patients,and the diagnostic efficiency of nCD64 combined with PCT is higher than that of nCD64 and PCT alone,which can be used to evaluate the severity of infection diseases in ACLF patients.
作者
董杰
钟曼华
郑颖
董韵
周晓蕾
DONG Jie;ZHONG Man-hua;ZHENG Ying;DONG Yun;ZHOU Xiao-lei(Department of Infectious disease,Zhuhai People’s Hospital,Guangdong 519000,China)
出处
《肝脏》
2021年第12期1378-1380,共3页
Chinese Hepatology
