摘要
慢加急性肝衰竭(Acute-on-chronic liver failure,ACLF)是以慢性肝病为基础,伴有多器官功能衰竭和较高病死率为特点的临床综合征。由于ACLF患者免疫功能紊乱,其具有较高的并发感染率。并发感染的早期诊断有助于启动早期抗感染治疗并改善患者预后,但ACLF并发感染易漏诊,寻找新的诊断方法和感染生物标志物,可帮助提高诊断的可靠性和准确性。本文从ACLF患者并发感染的流行病学和免疫方面特点,及这些特点对诊断的影响做一综述。
Acute-on-chronic liver failure(ACLF)is a clinical syndrome characterized by chronic liver disease,multiple organ failure and high mortality.ACLF patients have a high incidence of concurrent infection due to immune dysfunction.Early diagnosis of concurrent infection can initiate early anti-infection treatment and improve patient prognosis.However,ACLF complicated with infection is easy to be misdiagnosed,so searching for new diagnostic methods and biomarkers of infection can improve the reliability and accuracy of diagnosis.This article reviews the progress on epidemiology and immune-related characteristics,and their effect on diagnosis of concurrent infection in patients with ACLF.
作者
应高翔
杨英
吴凤天
陈智
Ying Gaoxiang;Yang Ying;Wu Fengtian;Chen Zhi(State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,the First Affiliated Hospital,Zhejiang University School of Medicine,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,Hangzhou 310003,China)
出处
《中华临床感染病杂志》
CSCD
2020年第2期140-148,共9页
Chinese Journal of Clinical Infectious Diseases
基金
国家自然科学基金(81700552)
浙江省中医药科技计划项目(2018ZA063)
国家"十三五"科技重大专项(2017ZX10202203)。
关键词
慢加急性肝衰竭
感染
免疫
诊断
Acute-on-chronic liver failure
Infection
Immunity
Diagnosis
