摘要
目的探究益气化瘀方结合神经妥乐平对脊髓型颈椎病术后患者神经功能恢复、生活质量及机体氧化应激反应的影响。方法选取2017年6月—2019年12月因脊髓型颈椎病在北京中医药大学东直门医院行颈椎前路人工间盘置换术的患者68例,随机分为对照组和观察组各34例。对照组术后采用神经妥乐平口服治疗,观察组术后采用神经妥乐平和益气化瘀方口服治疗,2组均连续治疗1个月。记录2组患者术前及术后2周、1个月、3个月、6个月、1年的颈椎JOA评分、生活质量NDI评分,于治疗前和治疗1个月后采用酶联免疫吸附法测定患者血清丙二醛(MDA)、总抗氧化能力(T-AOC)、去甲肾上腺素(NE)及皮质醇(Cor)水平。结果2组患者术后各时间段颈椎JOA评分均明显高于术前(P均<0.05);2组患者术前、术后2周、术后1个月、术后3个月颈椎JOA评分比较差异均无统计学意义(P均>0.05),观察组患者术后3个月、6个月、1年的颈椎JOA评分均明显高于对照组(P均<0.05)。2组患者术后各时间段NDI评分均明显低于术前(P均<0.05);观察组患者术后2周、1个月、3个月的NDI评分均明显低于对照组(P均<0.05);术后6个月和术后1年,2组NDI评分比较差异均无统计学意义(P均>0.05)。治疗1个月后,观察组血清MDA、NE及Cor水平均明显低于对照组,T-AOC水平明显高于对照组,差异均有统计学意义(P均<0.05)。结论益气化瘀方联合神经妥乐平治疗,在早期可通过消炎止痛、减轻氧化应激反应作用,减轻脊髓型颈椎病术后患者疼痛,保护神经,改善患者生活质量,在长期疗效中能够显著促进患者术后神经功能恢复。
Objective It is to explore the effects of Yiqi Huayu Decoction combined with Neurotropin on the recovery of nerve function,quality of life and oxidative stress response in patients with cervical spondylotic myelopathy after surgery.Methods A total of 68 patients with cervical spondylotic myelopathy who underwent anterior cervical artificial disc replacement in Dongzhimen Hospital of Beijing University of Chinese Medicine from June 2017 to December 2019 were selected and randomly divided into control group and observation group,with 34 cases in each group.The control group was treated with neurotropin orally after operation,and the observation group was treated with neurotropin and Yiqi Huayu Decoction orally after the operation.Both groups were continuously treated for 1 month.The cervical JOA scores and NDI scores of quality of life of the patients in the 2 groups were recorded before and 2 weeks,1 month,3 months,6 months,and 1 year after operation.The serum levels of malondialdehyde(MDA),total antioxidant capacity(T-AOC),norepinephrine(NE)and cortisol(Cor)were determined by enzyme-linked immunosorbent assay before treatment and 1 month after treatment.Results The JOA scores of the cervical spine at each postoperative time point were significantly higher than those before operation in the two groups(all P<0.05);there was no significant difference in the JOA scores of the cervical spine before operation,2 weeks,1 month,and 3 months after operation between the two groups(all P>0.05).The JOA scores of the cervical spine of the observation group were significantly higher than those of the control group at 3 months,6 months,and 1 year after surgery(all P<0.05).The NDI scores of the patients at each postoperative time point were significantly lower than those before operation in the two groups(all P<0.05);the NDI scores of the observation group were significantly lower than those of the control group at 2 weeks,1 month,and 3 months after surgery(all P<0.05),but there was no statistically significant difference in NDI
作者
陈江
孙悦礼
马增斌
李晋玉
白春晓
张帆
刘楚吟
赵学千
龙水文
冉宇
贾育松
CHEN Jiang;SUN Yueli;MA Zengbin;LI Jinyu;BAI Chunxiao;ZHANG Fan;LIU Chuyin;ZHAO Xueqian;LONG Shuiwen;RAN Yu;JIA Yusong(Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan, China;The Spine Institute of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China;Beijing Hospital/National Center for Geriatrics/Institute of Geriatrics, Chinese Academy of Medical Sciences, Beijing 100730, China)
出处
《现代中西医结合杂志》
CAS
2022年第1期21-25,共5页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
国家自然科学基金资助项目(81930116,81603638)
中国博士后科学基金面上项目(2019M662791)
北京市东城区优秀人才项目(2020-dchrcpyzz-29)
北京中医药大学2019年度基本科研业务费项目(2019-JYB-JS-042)。
关键词
益气化瘀方
神经妥乐平
脊髓型颈椎病
Yiqi Huayu Decoction
neurotropin
cervical spondylotic myelopathy
