摘要
目的评估继发性甲状旁腺功能亢进症患者行甲状旁腺全切除术的安全性及远期疗效。方法回顾性分析2012年3月至2018年3月在大连大学附属中山医院行甲状旁腺全切除术治疗继发性甲状旁腺功能亢进症154例患者的临床资料,观察术后血清甲状旁腺激素水平、血钙、磷水平、术后补钙的方法及剂量、临床症状。结果 154例患者中149例患者的血清甲状旁腺素水平波动于15~60 pg/ml,口服碳酸钙(1~2 g/次,3次/d)后血钙浓度波动于1.8~2.4 mg/ml,血磷浓度波动于0.8~1.6 mg/ml;5例患者血清甲状旁腺素水平波动于80~150 pg/ml,高于正常值的10~70 pg/ml。所有患者的临床症状均得到明显缓解。结论甲状旁腺全切除术治疗继发性甲状旁腺功能亢进症是安全、可靠的,复发率低,远期疗效满意。
Objective To evaluate the safety and long-term effect of total parathyroidectomy in patients with secondary hyperparathyroidism.Methods One hundred fifty-four patients with secondary hyperparathyroidism who underwent total parathyroidectomy in Zhongshan Hospital,Dalian University from Mar 2012 to Mar 2018 were followed up for 3-9 years,including the level of iPTH,serum calcium and phosphorus and dosing of calcium supplement.Results Among the 154 patients,the iPTH level in 149 patients fluctuated within 15-60 pg/ml.After oral calcium carbonate,the blood calcium fluctuated in 1.8-2.4 mg/ml,and serum phosphorus was 0.8-1.6 mg/ml.The level of iPTH in 5 patients was between 80-150 pg/ml,which was higher than the normal value 10-70 pg/ml.The clinical symptoms of all patients were significantly relieved.Conclusion Total parathyroidectomy is safe and reliable in the treatment of secondary hyperparathyroidism with low recurrence rate and stable long-term effect.
作者
魏林枫
李润生
赵晖
郑新
郝国强
邓芝徽
邢壮杰
Wei Linfeng;Li Runsheng;Zhao Hui;Zheng Xin;Hao Guoqiang;Deng Zhihui;Xing Zhuangjie(Department of General Surgery,Zhongshan Hospital of Dalian University,Dalian 116001,China;Department of General Surgery,Jiangdu People's Hospital,Yangzhou 225000,China)
出处
《中华普通外科杂志》
CSCD
北大核心
2021年第12期919-921,共3页
Chinese Journal of General Surgery
